ArticleEuropean stroke journal2024
Clinical course of patients with conservatively managed cerebral cavernous malformations.
Article in European stroke journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 9 citations in OpenAlex.
- Aspirin Use and the Risk of Symptomatic Hemorrhage in Patients With Cerebral Cavernous Malformations and Ischemic Cerebrovascular Disease.Stroke (Hoboken, N.J.) · 2026Article
- Incidence of cerebral cavernous malformations among adults in Scotland: a prospective, population-based study.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Clinical course and patient-reported outcomes in conservatively managed spinal cavernous malformations.Journal of neurology · 2026Article
- Treatment of patients with spinal cavernous malformations: a systematic review.Brain & spine · 2026Review
- Controversies in Cavernous Malformation Management: A Comprehensive Review of Current Literature.Journal of clinical medicine · 2025Review
- Long-term outcomes of untreated cerebral cavernous malformations: a prospective, population-based cohort study.The Lancet regional health. Europe · 2025Article
- Large Pontine Cavernoma with Hemorrhage: Case Report on Surgical Approach and Recovery.Journal of clinical medicine · 2025Article
- Gamma knife radiosurgery for cavernous malformations: a comprehensive study on symptom relief, hemorrhage rates, and histopathological changes.Neurosurgical review · 2025Article
- Exploration of treatment strategies for cerebral cavernous malformations: two case reports on non-resection treatment and literature review.Frontiers in oncology · 2025Article
- Patient-reported outcomes in conservatively managed cerebral cavernous malformations.Journal of neurology · 2024Observational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThere is uncertainty whether patients with a cerebral cavernous malformation (CCM) should undergo conservative or surgical treatment, resulting in practice variation among hospitals. Our objective was to report clinical outcomes of patients with primarily conservatively managed CCMs. PATIENTS AND
methodsThis single-center cohort study included consecutive adult CCM patients, diagnosed in 2000-2023, who underwent conservative management as primary treatment strategy. Data were extracted from medical records, and we systematically conducted telephone and questionnaire follow-up. Functional status was assessed on the modified Rankin Scale (mRS).
resultsOf 345 patients, we included 265 patients with a CCM (median age 46 years; 45% male). At baseline, 131 (49%) patients presented with symptomatic hemorrhage (SH), and 134 (51%) with other symptoms or asymptomatically. During 58 months (IQR 35-94) median follow-up, 51 (19%) patients experienced a SH, 33 (12%) a seizure, and 13 (5%) focal neurological deficits. Fourteen (5%) patients underwent intervention (surgery DISCUSSION AND
conclusionThe majority of conservatively managed CCM patients remained free of a SH during follow-up. Few patients required intervention, and death attributable to the CCM was rare. These data may help patient counseling and treatment decisions.
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