Evidence map›Paper›PMID 38623955›Full record

ReviewPhotochemistry and photobiology

The fusion of light and immunity: Advancements in photoimmunotherapy for melanoma.

Pranav Volety, Carl A Shirley, Gagan Chhabra, Nihal Ahmad

Open access · bronzeAbstract readReview
In one paragraph

Review in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pranav VoletyDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
Carl A ShirleyDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
Gagan ChhabraDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0001-5205-7218
Nihal AhmadDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
University of Wisconsin–Madison · US

Funding

Functional and Therapeutic Significance of PLK4 in MelanomaR01CA261937 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Nihal Ahmad · 2022 to 2026
$2.9M
Combined inhibition of PLK1 and NOTCH for melanoma managementI01BX005917 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI AHMAD, NIHAL · 2023 to 2025
–
Role of sirtuin 6 in melanoma development and progressionI01CX002210 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI Nihal Ahmad · 2022 to 2026
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BLRD Research Career Scientist Award ApplicationIK6BX006041 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI AHMAD, NIHAL · 2022 to 2025
–
BLRD VA I01 BX005917BLRD VA IK6 BX006041CSRD VA I01 CX002210NCI NIH HHS R01 CA261937NIH HHS R01CA261937U.S. Department of Veterans Affairs BLR&D I01BX005917U.S. Department of Veterans Affairs CSR&D I01CX002210
6 · The paper itself

Abstract

Metastatic melanoma is an aggressive skin cancer with high mortality and recurrence rates. Despite the clinical success of recent immunotherapy approaches, prevailing resistance rates necessitate the continued development of novel therapeutic options. Photoimmunotherapy (PIT) is emerging as a promising immunotherapy strategy that uses photodynamic therapy (PDT) to unleash systemic immune responses against tumor sites while maintaining the superior tumor-specificity and minimally invasive nature of traditional PDT. In this review, we discuss recent advances in PIT and strategies for the management of melanoma using PIT. PIT can strongly induce immunogenic cell death, inviting the concomitant application of immune checkpoint blockade or adoptive cell therapies. PIT can also be leveraged to selectively remove the suppressive immune populations associated with immunotherapy resistance. The modular nature of PIT therapy design combined with the potential for patient-specific antigen selection or drug co-delivery makes PIT an alluring option for future personalized melanoma care.

Indexed as

ImmunotherapyMelanomaPhotochemotherapyAnimalsHumansPhotosensitizing AgentsSkin NeoplasmsPhotosensitizing Agentsimmunotherapymelanomaphotodynamic therapyphotoimmunotherapyphototherapy

Identifiers

PMID38623955
PMCPMC11286352
OpenAlexW4394853691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.