ArticleOpen forum infectious diseases2024
Hepatitis B Virus Prevalence and Transmission in the Households of Pregnant Women in Kinshasa, Democratic Republic of Congo.
Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Vertical transmission of hepatitis B virus in the WHO African region: a systematic review and meta-analysis.The Lancet. Global health · 2025Pooled it
- Hepatitis B seroprevalence and knowledge awareness among spouses of reported Hepatitis B cases in Quzhou city: A cross-sectional study.Human vaccines & immunotherapeutics · 2026Article
- Hepatitis B Virus Diagnosis Using Dried Blood Spots in the D.R. Congo: Overcoming Misdiagnosis to Achieve 2030 WHO Targets.Medical sciences (Basel, Switzerland) · 2026Article
- Hepatitis B immunity and vaccine completion among adults at increased risk for hepatitis B infection in Zambia.PloS one · 2026Article
- Prevalence and factors associated with hepatitis B surface antigen (HBsAg) positivity in Bugoye Sub-County, Western Uganda.Discover public health · 2026Article
- Intra-familial transmission of Hepatitis B virus in a peri-urban community from the Democratic Republic of the Congo.Tropical medicine and health · 2025Article
- Children with hepatitis B virus infections, Democratic Republic of the Congo.Bulletin of the World Health Organization · 2025Article
- Revealing viral hepatitis epidemiology in the Democratic Republic of Congo: insights from yellow fever surveillance reanalysis.Tropical medicine and health · 2025Article
- Perceived shifts in routine vaccine confidence during the COVID-19 pandemic in Kinshasa Province, DRC: A mixed-methods approach.PLOS global public health · 2025Article
- Hepatitis B Elimination Globally: The Answer May Not Be the Same for Everyone.Journal of the Pediatric Infectious Diseases Society · 2024Article
- Characterizing hepatitis B virus infection in children in the Democratic Republic of Congo to inform elimination efforts.medRxiv : the preprint server for health sciences · 2024Article
- Low level of awareness and prevention of hepatitis B among Congolese healthcare workers: urgent need for policy implementation.Frontiers in public health · 2024Article
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Background: The World Health Organization Africa region has high regional hepatitis B virus (HBV) prevalence, and evidence suggests more frequent horizontal HBV transmission than other regions. Context-specific epidemiological studies are needed to inform additional HBV prevention measures. Methods: In the cross-sectional Horizontal and Vertical Transmission of Hepatitis B (HOVER-HBV) study, we introduced HBV surface antigen (HBsAg) screening alongside existing HIV screening as part of routine antenatal care in high-volume maternity clinics in Kinshasa, Democratic Republic of Congo. We recruited households of pregnant women ("index mothers") who were HBsAg-positive and HBsAg-negative, defining households as index-positive and index-negative, respectively. Household members underwent HBsAg testing and an epidemiological survey. We evaluated HBsAg prevalence and potential transmission correlates. Results: We enrolled 1006 participants from 200 households (100 index-positive, 100 index-negative) across Kinshasa. HBsAg-positivity prevalence was more than twice as high in index-positive households (5.0% [95% confidence interval {CI}, 2.8%-7.1%]) as in index-negative households (1.9% [95% CI, .6%-3.2%]). HBsAg-positivity prevalence was 3.3 (95% CI, .9-11.8) times as high among direct offspring in index-positive versus index-negative households. Factors associated with HBsAg positivity included older age, marriage, and having multiple recent partners or any new sexual partners among index mothers; and older age, lower household wealth, sharing nail clippers, and using street salons among offspring in index-positive households. Conclusions: Vertical and horizontal HBV transmission within households is ongoing in Kinshasa. Factors associated with infection reveal opportunities for HBV prevention efforts, including perinatal prevention, protection during sexual contact, and sanitation of shared personal items.
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