Evidence map›Paper›PMID 38623435›Full record

ReviewFood science and biotechnology2024

Application of experimental design as a statistical approach to recover bioactive peptides from different food sources.

Mikael Kélvin de Albuquerque Mendes, Christian Bremmer Dos Santos Oliveira, Carla Mariana da Silva Medeiros, Clecio Dantas, Emanuel Carrilho, Ana Rita de Araujo Nogueira, Cícero Alves Lopes Júnior, Edivan Carvalho Vieira

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Food science and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mikael Kélvin de Albuquerque MendesDepartamento de Química, Universidade Federal do Piauí - UFPI, P.O. Box 64049-550, Teresina, PI Brazil.
Christian Bremmer Dos Santos OliveiraDepartamento de Química, Universidade Federal do Piauí - UFPI, P.O. Box 64049-550, Teresina, PI Brazil.
Carla Mariana da Silva MedeirosDepartamento de Química, Universidade Federal do Piauí - UFPI, P.O. Box 64049-550, Teresina, PI Brazil.
Clecio DantasDepartamento de Química, Universidade Estadual do Maranhão - UEMA, P.O. Box, 65604-380, Caxias, MA Brazil.
Emanuel CarrilhoInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP 13566-590 Brazil.
Ana Rita de Araujo NogueiraEmbrapa Pecuária Sudeste, São Carlos, São Paulo 13560-970 Brazil.
Cícero Alves Lopes JúniorDepartamento de Química, Universidade Federal do Piauí - UFPI, P.O. Box 64049-550, Teresina, PI Brazil.ORCID 0000-0001-8379-8174
Edivan Carvalho VieiraDepartamento de Química, Universidade Federal do Piauí - UFPI, P.O. Box 64049-550, Teresina, PI Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioactive peptides (BAPs) derived from samples of animals and plants have been widely recommended and consumed for their beneficial properties to human health and to control several diseases. This work presents the applications of experimental designs (DoE) used to perform factor screening and/or optimization focused on finding the ideal hydrolysis condition to obtain BAPs with specific biological activities. The collection and discussion of articles revealed that Box Behnken Desing and Central Composite Design were the most used. The main parameters evaluated were pH, time, temperature and enzyme/substrate ratio. Among vegetable protein sources, soy was the most used in the generation of BAPs, and among animal proteins, milk and shrimp stood out as the most explored sources. The degree of hydrolysis and antioxidant activity were the most investigated responses in obtaining BAPs. This review brings new information that helps researchers apply these DoE to obtain high-quality BAPs with the desired biological activities.

Indexed as

Bioactive peptides (BAPs)Biological activitiesDesign of experimentsEnzymatic hydrolysisProteinsResponse surface methodology

Identifiers

PMID38623435
PMCPMC11016049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.