Evidence map›Paper›PMID 38623341›Full record

ArticleiScience2024

Genomic analysis of human brain metastases treated with stereotactic radiosurgery reveals unique signature based on treatment failure.

Jack M Shireman, Quinn White, Zijian Ni, Chitrasen Mohanty, Yujia Cai, Lei Zhao, Namita Agrawal, Nikita Gonugunta, Xiaohu Wang, Liam Mccarthy and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 4 institutions in 1 country.

Jack M ShiremanDepartment of Neurosurgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Quinn WhiteDepartment of Biostatistics and Medical Informatics, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Zijian NiDepartment of Biostatistics and Medical Informatics, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Chitrasen MohantyDepartment of Biostatistics and Medical Informatics, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Yujia CaiDepartment of Biostatistics and Medical Informatics, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Lei ZhaoDepartment of Neurosurgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Namita AgrawalDepartment of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
Nikita GonuguntaDepartment of Neurosurgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Xiaohu WangDepartment of Neurosurgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Liam MccarthyDepartment of Neurosurgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Varshitha KasulabadaDepartment of Neurosurgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Akshita PattnaikDepartment of Neurosurgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Atique U AhmedDepartment of Neurological Surgery, Northwestern University, Chicago, IL, USA.
James MillerDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Charles KulwinGoodman Campbell Brain and Spine Neurological Surgery, Indianapolis, IN, USA.
Aaron Cohen-GadolDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Troy PaynerGoodman Campbell Brain and Spine Neurological Surgery, Indianapolis, IN, USA.
Chih-Ta LinDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Jesse J SavageDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Brandon LaneDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Kevin ShiueDepartment of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
Aaron KamerDepartment of Clinical Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Mitesh ShahDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Gopal IyerDepartment of Human Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Gordon WatsonDepartment of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
Christina KendziorskiDepartment of Biostatistics and Medical Informatics, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
Mahua DeyDepartment of Neurosurgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA.
University of Wisconsin–Madison · USNeurological Surgery · USIndiana University School of MedicineNorthwestern University · US

Funding

Neuroscience Training ProgramT32NS105602 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Ari Rosenberg · 2019 to 2026
$2.5M
Plasmacytoid Dendritic Cells in Malignant GliomaK08NS092895 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DEY, MAHUA · 2016 to 2020
$917k
NINDS NIH HHS K08 NS092895NINDS NIH HHS T32 NS105602
6 · The paper itself

Abstract

Stereotactic radiosurgery (SRS) has been shown to be efficacious for the treatment of limited brain metastasis (BM); however, the effects of SRS on human brain metastases have yet to be studied. We performed genomic analysis on resected brain metastases from patients whose resected lesion was previously treated with SRS. Our analyses demonstrated for the first time that patients possess a distinct genomic signature based on type of treatment failure including local failure, leptomeningeal spread, and radio-necrosis. Examination of the center and peripheral edge of the tumors treated with SRS indicated differential DNA damage distribution and an enrichment for tumor suppressor mutations and DNA damage repair pathways along the peripheral edge. Furthermore, the two clinical modalities used to deliver SRS, LINAC and GK, demonstrated differential effects on the tumor landscape even between controlled primary sites. Our study provides, in human, biological evidence of differential effects of SRS across BM's.

Indexed as

CancerCancer systems biologyGenomic analysisGenomics

Identifiers

PMID38623341
PMCPMC11016778
OpenAlexW4393238338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.