Evidence map›Paper›PMID 38623325›Full record

ArticleiScience2024

Necl-1/CADM3 regulates cone synapse formation in the mouse retina.

Rumi Kawashima, Kenji Matsushita, Kenji Mandai, Yuko Sugita, Tomohiko Maruo, Kiyohito Mizutani, Yoshihiro Midoh, Akiko Oguchi, Yasuhiro Murakawa, Kazuki Kuniyoshi and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Rumi KawashimaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
Kenji MatsushitaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
Kenji MandaiDivision of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0047, Japan.
Yuko SugitaLaboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
Tomohiko MaruoDivision of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0047, Japan.
Kiyohito MizutaniDivision of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0047, Japan.
Yoshihiro MidohGraduate School of Information Science and Technology, Osaka University, Suita, Osaka 565-0871, Japan.
Akiko OguchiRIKEN-IFOM Joint Laboratory for Cancer Genomics, IMS RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Yasuhiro MurakawaRIKEN-IFOM Joint Laboratory for Cancer Genomics, IMS RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Kazuki KuniyoshiDepartment of Ophthalmology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan.
Ryohei SatoForefront Research Center for Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.
Takahisa FurukawaLaboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
Kohji NishidaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
Yoshimi TakaiDivision of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0047, Japan.
The University of Osaka · JPKitasato University · JPKobe University · JPRIKEN Center for Integrative Medical Sciences · JPKindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vertebrates, retinal neural circuitry for visual perception is organized in specific layers. The outer plexiform layer is the first synaptic region in the visual pathway, where photoreceptor synaptic terminals connect with bipolar and horizontal cell processes. However, molecular mechanisms underlying cone synapse formation to mediate OFF pathways remain unknown. This study reveals that Necl-1/CADM3 is localized at S- and S/M-opsin-containing cones and dendrites of type 4 OFF cone bipolar cells (CBCs). In

Indexed as

Biological sciencesMolecular neuroscienceNeuroscience;

Identifiers

PMID38623325
PMCPMC11016759
OpenAlexW4393204501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.