Evidence map›Paper›PMID 38622897›Full record

ArticleBrain and behavior2024

Pediatric traumatic brain injury and early age multiple sclerosis in Finland: A nationwide register-based cohort study.

Juho Laaksonen, Ville Ponkilainen, Ilari Kuitunen, Julius Möttönen, Ville M Mattila

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Juho LaaksonenSchool of Medicine, University of Tampere, Tampere, Finland.ORCID 0000-0002-9328-4721
Ville PonkilainenDepartment of Surgery, Hospital Nova of Central Finland, Jyväskylä, Finland.
Ilari KuitunenInstitute of Clinical Medicine and Department of Pediatrics, University of Eastern Finland, Kuopio, Finland.
Julius MöttönenInstitute of Clinical Medicine and Department of Pediatrics, University of Eastern Finland, Kuopio, Finland.
Ville M MattilaSchool of Medicine, University of Tampere, Tampere, Finland.
Tampere University · FIUniversity of Eastern Finland · FICentral Finland Health Care District · FI

Funding

Maire Taposen SäätiöPäivikki ja Sakari Sohlbergin SäätiöYrjö Jahnssonin Säätiö
6 · The paper itself

Abstract

objectiveExamine the link between pediatric traumatic brain injury (pTBI) and early-onset multiple sclerosis in Finland.

methodsConducted nationwide register study (1998-2018) with 28,750 pTBI patients (< 18) and 38,399 pediatric references with extremity fractures. Multiple sclerosis diagnoses from Finnish Social Insurance Institution. Employed Kaplan-Meier and multivariable Cox regression for probability assessment, results presented with 95% CI.

resultsOf 66 post-traumatic multiple sclerosis cases, 30 (0.10%) had pTBI, and 36 (0.09%) were in the reference group. Cumulative incidence rates (CIR) in the first 10 years were 46.5 per 100,000 (pTBI) and 33.1 per 100,000 (reference). Hazard ratio (HR) for pTBI was 1.10 (95% CI: 0.56-1.48).Stratified by gender, women's CIR was 197.9 per 100,000 (pTBI) and 167.0 per 100,000 (reference) after 15 years. For men, CIR was 44.6 per 100,000 (pTBI) and 34.7 per 100,000 (reference). In the initial 3 years, HR for female pTBI was 1.75 (95% CI: 0.05-6.32), and between years 3 and 20, it was 1.08 (95% CI: 0.51-1.67). For male patients, HR was 1.74 (95% CI: 0.69-4.39). SIGNIFICANCE: We did not find evidence of an association between pTBI and early-onset multiple sclerosis 20 years post-initial trauma.

Indexed as

Brain Injuries, TraumaticMultiple SclerosisChildCohort StudiesFemaleFinlandHumansMaleProportional Hazards Modelsmultiple sclerosispediatrictraumatic brain injury

Identifiers

PMID38622897
PMCPMC11019240
OpenAlexW4394853652

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.