Evidence map›Paper›PMID 38622703›Full record

ArticleBMC medical informatics and decision making2024

Identifying subgroups in heart failure patients with multimorbidity by clustering and network analysis.

Catarina Martins, Bernardo Neves, Andreia Sofia Teixeira, Miguel Froes, Pedro Sarmento, Jaime Machado, Carlos A Magalhães, Nuno A Silva, Mário J Silva, Francisca Leite

Open access · goldAbstract read
In one paragraph

Article in BMC medical informatics and decision making, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Catarina MartinsInstituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Bernardo NevesInstituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal. bernardoneves@tecnico.ulisboa.pt.
Andreia Sofia TeixeiraHospital da Luz Learning Health, Luz Saúde, Lisboa, Portugal.
Miguel FroesInstituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Pedro SarmentoHospital da Luz Lisboa, Internal Medicine, Luz Saúde, Lisboa, Portugal.
Jaime MachadoHospital da Luz Learning Health, Luz Saúde, Lisboa, Portugal.
Carlos A MagalhãesHospital da Luz Learning Health, Luz Saúde, Lisboa, Portugal.
Nuno A SilvaHospital da Luz Learning Health, Luz Saúde, Lisboa, Portugal.
Mário J SilvaInstituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Francisca LeiteHospital da Luz Learning Health, Luz Saúde, Lisboa, Portugal.
Hospital da Luz · PTInstituto Politécnico de Lisboa · PTUniversity of Lisbon · PTInstituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento · PT

Funding

ERDF/LISBOA2020 LISBOA-01-0247-FEDER-045948
6 · The paper itself

Abstract

This study presents a workflow for identifying and characterizing patients with Heart Failure (HF) and multimorbidity utilizing data from Electronic Health Records. Multimorbidity, the co-occurrence of two or more chronic conditions, poses a significant challenge on healthcare systems. Nonetheless, understanding of patients with multimorbidity, including the most common disease interactions, risk factors, and treatment responses, remains limited, particularly for complex and heterogeneous conditions like HF. We conducted a clustering analysis of 3745 HF patients using demographics, comorbidities, laboratory values, and drug prescriptions. Our analysis revealed four distinct clusters with significant differences in multimorbidity profiles showing differential prognostic implications regarding unplanned hospital admissions. These findings underscore the considerable disease heterogeneity within HF patients and emphasize the potential for improved characterization of patient subgroups for clinical risk stratification through the use of EHR data.

Indexed as

Heart FailureMultimorbidityChronic DiseaseCluster AnalysisComorbidityHumansCluster analysisDisease subtypingHeart failureMultimorbidityPhenotyping

Identifiers

PMID38622703
PMCPMC11020914
OpenAlexW4394808562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.