Evidence map›Paper›PMID 38622691›Full record

ArticleJournal of nanobiotechnology2024

Macrophages as carriers of boron carbide nanoparticles dedicated to boron neutron capture therapy.

Anna Wróblewska, Bożena Szermer-Olearnik, Agnieszka Szczygieł, Katarzyna Węgierek-Ciura, Jagoda Mierzejewska, Dawid Kozień, Paulina Żeliszewska, Roksana Kruszakin, Paweł Migdał, Zbigniew Pędzich and 1 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna WróblewskaHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland. anna.wroblewska@hirszfeld.pl.
Bożena Szermer-OlearnikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland.
Agnieszka SzczygiełHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland.
Katarzyna Węgierek-CiuraHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland.
Jagoda MierzejewskaHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland.
Dawid KozieńFaculty of Materials Science and Ceramics, Department of Ceramics and Refractory Materials, AGH University of Krakow, Krakow, Poland.
Paulina ŻeliszewskaJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Kracow, Poland.
Roksana KruszakinHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland.
Paweł MigdałHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland.
Zbigniew PędzichFaculty of Materials Science and Ceramics, Department of Ceramics and Refractory Materials, AGH University of Krakow, Krakow, Poland.
Elżbieta Pajtasz-PiaseckaHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland.

Funding

Narodowe Centrum Nauki 2019/33/B/NZ5/02212Narodowe Centrum Nauki 2022/45/N/NZ5/03204
6 · The paper itself

Abstract

backgroundThe use of cells as carriers for the delivery of nanoparticles is a promising approach in anticancer therapy, mainly due to their natural properties, such as biocompatibility and non-immunogenicity. Cellular carriers prevent the rapid degradation of nanoparticles, improve their distribution, reduce cytotoxicity and ensure selective delivery to the tumor microenvironment. Therefore, we propose the use of phagocytic cells as boron carbide nanoparticle carriers for boron delivery to the tumor microenvironment in boron neutron capture therapy.

resultsMacrophages originating from cell lines and bone marrow showed a greater ability to interact with boron carbide (B

conclusionsMacrophages could be promising cellular carriers for boron carbide nanoparticle delivery, especially B

Indexed as

Boron Neutron Capture TherapyNanoparticlesBoronCell Line, TumorMacrophagesBoronBoron carbideBoron neutron capture therapyCellular carriersDendritic cellsMacrophagesNanoparticles

Identifiers

PMID38622691
PMCPMC11017526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.