Evidence map›Paper›PMID 38622674›Full record

ArticleTrials2024

The (cost-)effectiveness of early intervention (MBT-early) versus standard protocolized treatment (CBT) for emerging borderline personality disorder in adolescents (the EARLY study): a study protocol for a randomized controlled trial.

Melissa G A Remeeus, Sharon L Clarke, Dine J Feenstra, Hester Van Eeren, Maaike L Smits, Sara Debruyne, Mirjam E J Kouijzer, Patrick Luyten, Ron H J Scholte, Joost Hutsebaut

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Melissa G A RemeeusBehavioural Science Institute, Radboud University, Thomas Van Aquinostraat 4, Nijmegen, 6525GD, The Netherlands. melissa.remeeus@deviersprong.nl.ORCID http://orcid.org/0000-0003-3178-2765
Sharon L ClarkeViersprong Institute for Studies on Personality Disorders, Peter Vineloolaan 50, Bergen Op Zoom, 4611AN, The Netherlands.
Dine J FeenstraViersprong Institute for Studies on Personality Disorders, Peter Vineloolaan 50, Bergen Op Zoom, 4611AN, The Netherlands.
Hester Van EerenDepartment of Medical Psychology and Psychotherapy, Erasmus MC, Dr. Molewaterplein 40, Rotterdam, 3015GD, The Netherlands.
Maaike L SmitsViersprong Institute for Studies on Personality Disorders, Peter Vineloolaan 50, Bergen Op Zoom, 4611AN, The Netherlands.
Sara DebruyneMentaal Beter, Steijnlaan 12, Hilversum, 1217JS, The Netherlands.
Mirjam E J KouijzerGGz Breburg, Poolseweg 190, Breda, 4818CG, The Netherlands.
Patrick LuytenFaculty of Psychology and Educational Sciences, University of Leuven, Dekenstraat 2, Leuven, 3000, Belgium.
Ron H J ScholteBehavioural Science Institute, Radboud University, Thomas Van Aquinostraat 4, Nijmegen, 6525GD, The Netherlands.
Joost HutsebautViersprong Institute for Studies on Personality Disorders, Peter Vineloolaan 50, Bergen Op Zoom, 4611AN, The Netherlands.

Funding

ZonMw 636310021
6 · The paper itself

Abstract

backgroundAlthough clinical guidelines prioritize the treatment of depression and anxiety in young persons, there is accumulating evidence that the presence of symptoms of borderline personality disorder (BPD) is associated with the limited effectiveness of these standard treatments. These findings stress the need for interventions addressing early-stage BPD in young people with presenting symptoms of anxiety and depressive disorders. The aim of this study is to investigate the (cost-)effectiveness of an early intervention programme for BPD (MBT-early) compared to first-choice psychological treatment for depression and anxiety according to Dutch treatment guidelines (CBT), in adolescents with either depression, anxiety, or both, in combination with early-stage BPD.

methodsThis study is a multi-centre randomized controlled trial. A total of 132 adolescents, presenting with either depression, anxiety, or both and significant BPD features will be randomized to either MBT-early or CBT. The severity of BPD, symptoms of depression and anxiety, personality, social and academic functioning, and quality of life will be assessed at baseline, end of treatment, and at 12-, 18-, and 24-month follow-up, along with medical costs and costs of productivity losses for cost-effectiveness analyses. DISCUSSION: This study will provide an empirical evaluation of the potential surplus value of early intervention in young people for whom treatment oriented at common mental disorders like anxiety and depression may be insufficient given their underlying personality problems.

trial registrationNetherlands Trial Register, NL9569. Registered on June 15, 2021.

Indexed as

Borderline Personality DisorderQuality of LifeAdolescentAnxietyEarly Intervention, EducationalHumansMulticenter Studies as TopicPersonalityRandomized Controlled Trials as TopicTreatment OutcomeAdolescentAnxiety disorderBorderline personality disorder (BPD)Cognitive behavioural therapy (CBT)Depressive disorderEarly interventionMentalizationRandomized controlled trial (RCT)

Identifiers

PMID38622674
PMCPMC11017502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.