Evidence map›Paper›PMID 38622667›Full record

ArticleJournal of translational medicine2024

Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.

Qiao Jin, Chiyuan Zhang, Ran Chen, Luping Jiang, Hongli Li, Pengcui Wu, Liang Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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  12. Loss of LXRβ Drives CD4Biomedicines · 2026
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  13. The Probiotic Effects ofInternational journal of microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Qiao JinDepartment of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China.
Chiyuan ZhangDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ran ChenDepartment of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China.
Luping JiangDepartment of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China.
Hongli LiDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, 410000, China.
Pengcui WuDepartment of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China. 2018050643@usc.edu.cn.
Liang LiDepartment of Cardiovascular Medicine, Hengyang Medical School, The Changsha central Affiliated Hospital, University of South China, Changsha, Hunan, 410004, China. 2018050640@usc.edu.cn.
University of South China · CNCentral South University · CNXiangya Hospital Central South University · CN

Funding

Changsha Municipal Health and Wellness Committee Fund No. KJ-A2023001Natural Science Foundation of Hunan Province No. 2022JJ30631Natural Science Foundation of Hunan Province No. 2023JJ60072
6 · The paper itself

Abstract

backgroundQuinic acid (QA) and its derivatives have good lipid-lowering and hepatoprotective functions, but their role in atherosclerosis remains unknown. This study attempted to investigate the mechanism of QA on atherogenesis in Apoe-/- mice induced by HFD.

methodsHE staining and oil red O staining were used to observe the pathology. The PCSK9, Mac-3 and SM22a expressions were detected by IHC. Cholesterol, HMGB1, TIMP-1 and CXCL13 levels were measured by biochemical and ELISA. Lipid metabolism and the HMGB1-SREBP2-SR-BI pathway were detected by PCR and WB. 16 S and metabolomics were used to detect gut microbiota and serum metabolites.

resultsQA or low-frequency ABX inhibited weight gain and aortic tissue atherogenesis in HFD-induced Apoe-/- mice. QA inhibited the increase of cholesterol, TMA, TMAO, CXCL13, TIMP-1 and HMGB1 levels in peripheral blood of Apoe-/- mice induced by HFD. Meanwhile, QA or low-frequency ABX treatment inhibited the expression of CAV-1, ABCA1, Mac-3 and SM22α, and promoted the expression of SREBP-1 and LXR in the vascular tissues of HFD-induced Apoe-/- mice. QA reduced Streptococcus_danieliae abundance, and promoted Lactobacillus_intestinalis and Ileibacterium_valens abundance in HFD-induced Apoe-/- mice. QA altered serum galactose metabolism, promoted SREBP-2 and LDLR, inhibited IDOL, FMO3 and PCSK9 expression in liver of HFD-induced Apoe-/- mice. The combined treatment of QA and low-frequency ABX regulated microbe-related Glycoursodeoxycholic acid and GLYCOCHENODEOXYCHOLATE metabolism in HFD-induced Apoe-/- mice. QA inhibited TMAO or LDL-induced HCAECs damage and HMGB1/SREBP2 axis dysfunction, which was reversed by HMGB1 overexpression.

conclusionsQA regulated the gut-liver lipid metabolism and chronic vascular inflammation of TMA/TMAO through gut microbiota to inhibit the atherogenesis in Apoe-/- mice, and the mechanism may be related to the HMGB1/SREBP2 pathway.

Indexed as

AtherosclerosisGastrointestinal MicrobiomeHMGB1 ProteinMethylaminesAnimalsApolipoproteins ECholesterolInflammationLipid MetabolismMiceMice, Inbred C57BLMice, Knockout, ApoEProprotein Convertase 9Quinic AcidSterol Regulatory Element Binding Protein 1Tissue Inhibitor of Metalloproteinase-1Apolipoproteins ECholesterolHMGB1 ProteinMethylaminesPCSK9 protein, humanProprotein Convertase 9Quinic AcidSterol Regulatory Element Binding Protein 1Tissue Inhibitor of Metalloproteinase-1trimethyloxamineAtherosclerosisGut microbiotaMetabolismQuinic acidTMAO

Identifiers

PMID38622667
PMCPMC11017595
OpenAlexW4394813178

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.