Evidence map›Paper›PMID 38622617›Full record

ReviewCancer cell international2024

Micropeptides: potential treatment strategies for cancer.

He Zhou, Yan Wu, Ji Cai, Dan Zhang, Dongfeng Lan, Xiaofang Dai, Songpo Liu, Tao Song, Xianyao Wang, Qinghong Kong and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancer cell international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Non-Coding RNAs in Oral Diseases: From Pathogenesis to Clinical Translation.International journal of molecular sciences · 2026
    Review
  2. Article
  3. The hidden players: LncRNA-Encoded micropeptides in cancer hallmarks.Cellular and molecular life sciences : CMLS · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

He ZhouDepartment of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, China.
Yan WuDepartment of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, China.
Ji CaiDepartment of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, China.
Dan ZhangZunyi Medical University Library, Zunyi, 563000, China.
Dongfeng LanDepartment of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, China.
Xiaofang DaiDepartment of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, China.
Songpo LiuDepartment of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, China.
Tao SongDepartment of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, China.
Xianyao WangDepartment of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, China.
Qinghong KongGuizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi563000, China.
Zhixu HeCollaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University, Zunyi, 563000, China. hzx@gmc.edu.cn.
Jun TanDepartment of Histology and Embryology, Zunyi Medical University, Zunyi, 563000, China. juntan@zmu.edu.cn.
Jidong ZhangDepartment of Immunology, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, China. jdzhang0851@163.com.
Zunyi Medical University · CN

Funding

Collaborative Innovation Center of Chinese Ministry of Education 2020-39National Nature Science Foundation of China NSFC. 31960156, 31660338, 32270848Science and Technology Fund of Guizhou Provincial Health Commission gzwkj2022-019Science and Technology Support Program of Guizhou Province QKH[2020]4Y192, QKH[2019]5406, QKH-ZK[2021]111
6 · The paper itself

Abstract

Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although noncoding RNAs (ncRNAs) have been previously assumed to constitute a class of RNA transcripts without coding capacity. Furthermore, recent studies have revealed that ncRNA-derived micropeptides exhibit regulatory functions in the development of many tumours. Although some of these micropeptides inhibit tumour growth, others promote it. Understanding the role of ncRNA-encoded micropeptides in cancer poses new challenges for cancer research, but also offers promising prospects for cancer therapy. In this review, we summarize the types of ncRNAs that can encode micropeptides, highlighting recent technical developments that have made it easier to research micropeptides, such as ribosome analysis, mass spectrometry, bioinformatics methods, and CRISPR/Cas9. Furthermore, based on the distribution of micropeptides in different subcellular locations, we explain the biological functions of micropeptides in different human cancers and discuss their underestimated potential as diagnostic biomarkers and anticancer therapeutic targets in clinical applications, information that may contribute to the discovery and development of new micropeptide-based tools for early diagnosis and anticancer drug development.

Indexed as

CancerMicropeptideNoncoding RNAsSubcellular localization

Identifiers

PMID38622617
PMCPMC11020647
OpenAlexW4394810074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.