ArticleBMC psychiatry2024
Brain structural alterations associated with impulsiveness in male violent patients with schizophrenia.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Hippocampal subfield radiomics improves identification of in-hospital aggressive behavior in schizophrenia: an interpretable machine-learning study.BMC psychiatry · 2026Article
- Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium.Molecular psychiatry · 2026Article
- Nursing strategies for implementing psychosocial interventions to address violence behavior in schizophrenia: a scoping review.BMC nursing · 2025Article
- Role of peripheral cytokines and orbitofrontal cortex subregion structure in schizophrenia agitation.Scientific reports · 2025Article
- Construction of a troublemaking risk assessment tool for patients with severe mental disorders in community of China.Scientific reports · 2025Article
- Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundViolence in schizophrenia (SCZ) is a phenomenon associated with neurobiological factors. However, the neural mechanisms of violence in patients with SCZ are not yet sufficiently understood. Thus, this study aimed to explore the structural changes associated with the high risk of violence and its association with impulsiveness in patients with SCZ to reveal the possible neurobiological basis.
methodThe voxel-based morphometry approach and whole-brain analyses were used to measure the alteration of gray matter volume (GMV) for 45 schizophrenia patients with violence (VSC), 45 schizophrenia patients without violence (NSC), and 53 healthy controls (HC). Correlation analyses were used to examine the association of impulsiveness and brain regions associated with violence.
resultsThe results demonstrated reduced GMV in the right insula within the VSC group compared with the NSC group, and decreased GMV in the right temporal pole and left orbital part of superior frontal gyrus only in the VSC group compared to the HC group. Spearman correlation analyses further revealed a positive correlation between impulsiveness and GMV of the left superior temporal gyrus, bilateral insula and left medial orbital part of the superior frontal gyrus in the VSC group.
conclusionOur findings have provided further evidence for structural alterations in patients with SCZ who had engaged in severe violence, as well as the relationship between the specific brain alterations and impulsiveness. This work provides neural biomarkers and improves our insight into the neural underpinnings of violence in patients with SCZ.
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