Evidence map›Paper›PMID 38622478›Full record

ArticleMolecular biology reports2024

The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na

Katarina Banjac, Milan Obradovic, Sonja Zafirovic, Magbubah Essack, Zoran Gluvic, Milos Sunderic, Olgica Nedic, Esma R Isenovic

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Katarina BanjacDepartment of Radiobiology and Molecular Genetics, "VINCA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, P.O.Box 522, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0001-6100-3887
Milan ObradovicDepartment of Radiobiology and Molecular Genetics, "VINCA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, P.O.Box 522, Belgrade, 11000, Serbia. obradovicmilan@hotmail.com.ORCID http://orcid.org/0000-0002-4769-2652
Sonja ZafirovicDepartment of Radiobiology and Molecular Genetics, "VINCA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, P.O.Box 522, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0002-5486-0079
Magbubah EssackComputational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0003-2709-5356
Zoran GluvicClinic of Internal Medicine, School of Medicine, University Clinical-Hospital Centre Zemun-Belgrade, University of Belgrade, Vukova 9, Belgrade, 11080, Serbia.ORCID http://orcid.org/0000-0001-6371-6610
Milos SundericInstitute for the Application of Nuclear Energy, Department for Metabolism, University of Belgrade, Banatska 31b, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-0940-9481
Olgica NedicInstitute for the Application of Nuclear Energy, Department for Metabolism, University of Belgrade, Banatska 31b, Belgrade, Serbia.ORCID http://orcid.org/0000-0003-2042-0056
Esma R IsenovicDepartment of Radiobiology and Molecular Genetics, "VINCA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, P.O.Box 522, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0002-0012-2636
University of Belgrade · RSKing Abdullah University of Science and Technology · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe previously demonstrated that insulin-like growth factor-1 (IGF-1) regulates sodium/potassium adenosine triphosphatase (Na METHODS AND

resultsThere were 14 adult male Wistar rats, half of whom received bolus injections of IGF-1 (50 μg/kg) for 24 h. We evaluated cardiac Na

conclusionThese results indicate that the Akt/mTOR/S6K signalling pathway may be involved in the IGF-1 regulating cardiac Na

Indexed as

Insulin-Like Growth Factor IProto-Oncogene Proteins c-aktAnimalsMalePhosphatidylinositol 3-KinasesPhosphorylationRatsRats, WistarRibosomal Protein S6 KinasesSodium-Potassium-Exchanging ATPaseTOR Serine-Threonine KinasesInsulin-Like Growth Factor ImTOR protein, ratPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRibosomal Protein S6 KinasesSodium-Potassium-Exchanging ATPaseTOR Serine-Threonine KinasesHeartIGF-1mTORNa+/K+-ATPaseS6K

Identifiers

PMID38622478
OpenAlexW4394820791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.