Evidence map›Paper›PMID 38622445›Full record

Observational studyHepatology international2024

PIVKA-II combined with alpha-fetoprotein for the diagnostic value of hepatic tumors in children: a multicenter, prospective observational study.

Hongxiang Gao, Chenjie Xie, Jing Wang, Ji Ma, Shijian Liu, Li Xie, Yijie Zheng, Rui Dong, Shan Wang, Yongjun Fang and 8 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Hepatology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03645655 (PIVKA-II Combined With Alpha-Fetoprotein for Diagnostic and Prognostic Value of Hepatic Tumors in Infants), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03645655 completednot on this map

PIVKA-II Combined With Alpha-Fetoprotein for Diagnostic and Prognostic Value of Hepatic Tumors in Infants: Protocol for a Multicenter, Observational Study

TypeobservationalSponsorShanghai Children's Medical CenterRan2018 to 2021Enrolled257ConditionsHepatoblastoma, Hepatic HemangioendotheliomaArmsPIVKA-II
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 1 country.

Hongxiang Gao *Department of Pediatric General Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Dongfang Road No. 1678, Pudong New District, Shanghai, 200127, China.
Chenjie Xie *Department of Pediatric General Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Dongfang Road No. 1678, Pudong New District, Shanghai, 200127, China.
Jing WangDepartment of Pediatric General Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Dongfang Road No. 1678, Pudong New District, Shanghai, 200127, China.
Ji MaDepartment of Laboratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Shijian LiuChild Health Advocacy Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Li XieClinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Yijie ZhengDepartment of Medical Affairs, Wuxidiagnotics, Shanghai, 200131, China.
Rui DongDepartment of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, 201102, China.
Shan WangDepartment of Pediatric Surgical Oncology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Yongjun FangDepartment of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Yurui WuDepartment of Minimally Invasive Surgery, Qilu Children's Hospital of Shandong University, Jinan, 250022, Shandong, China.
Xianwei ZhangDepartment of Oncology Surgery, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China.
Xianying LuDepartment of Pediatric Surgery, Anhui Provincial Children's Hospital, Hefei, 230051, China.
Yang LiDepartment of Pediatric Hematology/Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 519000, China.
Weisong LiDepartment of General Surgery, Pediatric Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Qiuhui PanDepartment of Laboratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Min XuDepartment of Pediatric General Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Dongfang Road No. 1678, Pudong New District, Shanghai, 200127, China. jackxm1236@126.com.
Song GuDepartment of Pediatric General Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Dongfang Road No. 1678, Pudong New District, Shanghai, 200127, China. gusong@shsmu.edu.cn.
Shanghai Jiao Tong University · CNShanghai Children's Medical Center · CNAnhui Medical University · CNAnhui Provincial Children's Hospital · CNChildren's Hospital of Fudan University · CNChongqing Medical University · CNQilu Hospital of Shandong University · CNSecond Affiliated Hospital of Nanjing Medical University · CNSun Yat-sen Memorial Hospital · CNZhengzhou University · CN

Funding

Joint project of Pudong New Area Municipal Health Commission of Shanghai PW2019D-10Medium-and long-term clinical research project (3311 project) of Shanghai Children's Medical Center ZCQ-SCMC2018-6National Natural Science Foundation of China 81871727National Natural Science Foundation of China 82072375Project of Shanghai Science and Technology Committee 17411950402Project of Shanghai Science and Technology Committee 17441903200Science and Technology Development Fund of Pudong New Area of Shanghai PKJ2019-Y11Science and Technology Development Fund of Shanghai Pudong New Area PKJ2017-Y04the national key clinical specialty project The construction of multidisciplinary cooperative diagnosisthe national key clinical specialty project treatment system for children's cancer guided by improving clinical service capacity
6 · The paper itself

Abstract

backgroundTo investigate whether protein induced by vitamin K antagonist-II (PIVKA-II) combined with alpha-fetoprotein (AFP) can improve the diagnostic and differential diagnostic accuracy of childhood hepatic tumors.

methodsA multi-center prospective observational study was performed at nine regional institutions around China. Children with hepatic mass (Group T) were divided into hepatoblastoma group (Group T

resultsThe mean levels of PIVKA-II and AFP were both significantly higher in Group T than Group C (p = 0.001, p < 0.001), in Group T

conclusionsThe serum level of PIVKA-II was significantly higher in children with hepatic tumors, especially those with malignant tumors. The combination of PIVKA-II with AFP further increased the diagnostic performance.

trial registrationClinical Trials, NCT03645655. Registered 20 August 2018, https://www. CLINICALTRIALS: gov/ct2/show/NCT03645655 .

Indexed as

alpha-FetoproteinsBiomarkers, TumorLiver NeoplasmsProtein PrecursorsBiomarkersChildChild, PreschoolChinaDiagnosis, DifferentialFemaleHepatoblastomaHumansInfantMaleProspective StudiesProthrombinacarboxyprothrombinalpha-FetoproteinsBiomarkersBiomarkers, TumorProtein PrecursorsProthrombinAlpha-fetoproteinBiomarkerChildrenDiagnosticHemangioendotheliomaHepatic tumorHepatoblastomaHistopathologyMalignant tumorProtein induced by vitamin K antagonist-II

Identifiers

PMID38622445
PMCPMC11297896
OpenAlexW4394853116

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.