Evidence map›Paper›PMID 38622110›Full record

ArticleNature communications2024

Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study.

Hilde Marie Engjom, Rema Ramakrishnan, Nicola Vousden, Kathryn Bunch, Edward Morris, Nigel Simpson, Chris Gale, Pat O'Brien, Maria Quigley, Peter Brocklehurst and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07257952 (An Observational Study on the Risk of Adverse Maternal and Infant Outcomes Associated With Respiratory Viral Infections Before and During Early Pregnancy), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07257952 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

An Observational Study on the Risk of Adverse Maternal and Infant Outcomes Associated With Respiratory Viral Infections Before and During Early Pregnancy

TypeobservationalSponsorShanghai General Hospital, ChinaRan2026 to 2028Enrolled1,440ConditionsRespiratory Viral Infections, Adverse Pregnancy Outcomes
3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  14. Did COVID-19 impact perinatal outcomes differently in public and private maternity hospitals in Brazil?Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hilde Marie Engjom *National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.ORCID http://orcid.org/0000-0003-1582-4283
Rema Ramakrishnan *National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Nicola Vousden *National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Kathryn BunchNational Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Edward MorrisNorfolk and Norwich University Hospital, Colney Lane, Norwich, NR4 7UY, UK.
Nigel SimpsonDepartment of Women's and Children's Health, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.ORCID http://orcid.org/0000-0002-0758-7583
Chris GaleNeonatal Medicine, School of Public Health, Faculty of Medicine, London, London, UK, SW7 2BX and Centre for Paediatrics and Child Health, Imperial College, London, SW7 2AZ, UK.
Pat O'BrienNorfolk and Norwich University Hospital, Colney Lane, Norwich, NR4 7UY, UK.
Maria QuigleyNational Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Peter BrocklehurstBirmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Jennifer J KurinczukNational Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Marian KnightNational Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK. Marian.knight@npeu.ox.ac.uk.ORCID http://orcid.org/0000-0002-1984-4575

Funding

DH | National Institute for Health Research (NIHR) NIHR201333DH | NIHR | Health Services and Delivery Research Programme (HS&DR Programme) 11/46/12Norges Forskningsråd (Research Council of Norway) 320181
6 · The paper itself

Abstract

There are few population-based studies of sufficient size and follow-up duration to have reliably assessed perinatal outcomes for pregnant women hospitalised with SARS-CoV-2 infection. The United Kingdom Obstetric Surveillance System (UKOSS) covers all 194 consultant-led UK maternity units and included all pregnant women admitted to hospital with an ongoing SARS-CoV-2 infection. Here we show that in this large national cohort comprising two years' active surveillance over four SARS-CoV-2 variant periods and with near complete follow-up of pregnancy outcomes for 16,627 included women, severe perinatal outcomes were more common in women with moderate to severe COVID-19, during the delta dominant period and among unvaccinated women. We provide strong evidence to recommend continuous surveillance of pregnancy outcomes in future pandemics and to continue to recommend SARS-CoV-2 vaccination in pregnancy to protect both mothers and babies.

Indexed as

COVID-19Pregnancy Complications, InfectiousCohort StudiesCOVID-19 VaccinesFemaleHumansPregnancyPregnancy OutcomeSARS-CoV-2COVID-19 Vaccines

Identifiers

PMID38622110
PMCPMC11018846

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.