ArticleActas espanolas de psiquiatria2024
Relationship between Pain and Dementia: The Mediating Effect of Depression among Chinese Elderly.
Article in Actas espanolas de psiquiatria, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of prevalence of pain among people with dementia living in the community.BMC neurology · 2026Pooled it
- Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review.Brain and behavior · 2025Pooled it
- Cumulative adverse childhood experiences increase migraine risk in later life in China: evidence from CHARLS with mediation and Mendelian randomization.The journal of headache and pain · 2026Article
- Depressive Symptoms as a Potential Mediator in the Association Between Pain and Cognitive Function: A Cross-Sectional Study.Journal of pain research · 2026Article
- Exploring the relationship between pain, cognition, and chronic conditions: insights from the HAALSI study in rural South Africa.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Explainable machine learning models for identifying mild cognitive impairment in older patients with chronic pain.BMC nursing · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundChronic pain poses a significant problem for older adults and may potentially impact cognitive function. This study aimed to examine the cross-sectional relationship between pain severity and cognitive function in elderly individuals residing in the community. Additionally, this study sought to examine the mediating effect of depression on the relationship between pain and dementia.
methodsThe study sample was derived from the 2018 China Health and Aging Longitudinal Study (CHARLS), comprising cross-sectional data from 4559 community residents aged 65 years or older. The primary outcome assessed was the occurrence of dementia, while the main independent variable was pain severity (none, little, somewhat, quite a bit, very). Depression score served as the mediating factor. Chi-square and binary logistic regression analyses were performed to examine the relationship between depression and the occurrence of pain and dementia. An intermediate model was constructed by stepwise regression.
resultsThe study indicates a significant association between cognitive impairment and both chronic pain and depressive symptoms in older adults living in China. Individuals who frequently report experiencing pain exhibit a higher likelihood of developing dementia when compared to those who do not report any pain (odds ratio (OR) = 1.72, p < 0.001). Moreover, depressive symptoms significantly mediate the relationship between pain and dementia, with the mediating effect accounting for 65.25%.
conclusionsChronic pain not only directly impacts patients' cognitive function but also indirectly exacerbates cognitive impairment through depressive symptoms as a mediating variable. For elderly individuals experiencing depressive symptoms, it is important to provide appropriate psychological treatment in conjunction with pain management strategies.
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