Evidence map›Paper›PMID 38621677›Full record

ArticleJournal of the American Chemical Society2024

Late-Stage Saturation of Drug Molecules.

De-Hai Liu, Philipp M Pflüger, Andrew Outlaw, Lukas Lückemeier, Fuhao Zhang, Clinton Regan, Hamid Rashidi Nodeh, Tim Cernak, Jiajia Ma, Frank Glorius

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
7.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Iridium-Catalyzed Ionic Hydrogenation of Multi-Aza Heterocycles.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Article
  5. Article
  6. Generalized Analysis of Electrophilic Small Molecules.Angewandte Chemie (International ed. in English) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

De-Hai LiuFrontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering and Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Philipp M PflügerOrganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany.
Andrew OutlawDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Lukas LückemeierOrganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany.
Fuhao ZhangOrganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany.
Clinton ReganDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Hamid Rashidi NodehDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Tim CernakDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-5407-0643
Jiajia MaFrontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering and Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.ORCID 0000-0002-4339-0462
Frank GloriusOrganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany.ORCID 0000-0002-0648-956X
University of Michigan · USUniversity of Münster · DEShanghai Jiao Tong University · CN

Funding

New Amine-Acid Couplings and Their Impact on Medicinal PropertiesR01GM144471 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CERNAK, TIMOTHY · 2022 to 2025
$1.6M
NIGMS NIH HHS R01 GM144471
6 · The paper itself

Abstract

The available methods of chemical synthesis have arguably contributed to the prevalence of aromatic rings, such as benzene, toluene, xylene, or pyridine, in modern pharmaceuticals. Many such sp

Indexed as

RhodiumCatalysisHydrogenationMolecular StructurePharmaceutical PreparationsPharmaceutical PreparationsRhodium

Identifiers

PMID38621677
PMCPMC11066876
OpenAlexW4394821018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.