Evidence map›Paper›PMID 38621447›Full record

ArticleArchives of biochemistry and biophysics2024

DTYMK is an essential gene in mice and heterozygosity does not cause neural tube defects.

Kendra A Tiani, Patrick J Stover

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kendra A TianiDivision of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.
Patrick J StoverCollege of Agriculture and Life Sciences, Texas A&M University, College Station, TX, 77843-2142, USA. Electronic address: patrick.stover@ag.tamu.edu.
Cornell University · USTexas A&M University · US

Funding

Homeostatic Regulation of Folate MetabolismR37DK058144 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI STOVER, PATRICK J · 2012 to 2021
$3.7M
Homeostatic Regulation of Folate MetabolismR01DK058144 · NIDDK · CORNELL UNIVERSITY ITHACA · PI STOVER, PATRICK J · 2002 to 2010
$2.9M
REGULATION OF FOLATE CATABOLISMR01HD035687 · NICHD · CORNELL UNIVERSITY ITHACA · PI STOVER, PATRICK J · 1997 to 2007
$2.2M
NICHD NIH HHS R01 HD035687NIDDK NIH HHS R01 DK058144NIDDK NIH HHS R37 DK058144
6 · The paper itself

Abstract

Regulation of nucleotide biosynthesis is necessary for maintaining cellular processes including DNA replication and repair. A key enzyme in this process is deoxythymidylate kinase (dTYMK), which catalyzes the initial step in the production of dTTP from dTMP. This gene constitutes the first merged step of dTTP synthesis from the de novo and salvage pathways which regulate dTMP biosynthesis. Decreased de novo dTMP biosynthesis causes dysregulated dTTP:dUTP pools, and leads to increased uracil in DNA and neural tube closure defect (NTD) development in mice. The goal of this research was to investigate if dTYMK, the downstream enzyme in dTTP production, is an essential gene in mice and if impairments in dTYMK play a causal role in development including NTD pathology in mice. Dtymk

Indexed as

Genes, EssentialNeural Tube DefectsNucleoside-Phosphate KinaseAnimalsFemaleHeterozygoteMiceMice, Inbred C57BLMice, KnockoutNucleoside-Phosphate KinaseDeoxythymidylate kinaseDeoxyuridineFolate-mediated one carbon metabolismFolic acidNeural tube defectsThymidylate synthesis

Identifiers

PMID38621447
PMCPMC11811913
OpenAlexW4394823647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.