Evidence map›Paper›PMID 38621251›Full record

ReviewAnnual review of vision science2024

Presynaptic Proteins and Their Roles in Visual Processing by the Retina.

Wallace B Thoreson, David Zenisek

Abstract readReview
In one paragraph

Review in Annual review of vision science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. X-Ray Irradiation Improved WSeNanomaterials (Basel, Switzerland) · 2025
    Article
  8. Syntaxin 3B: A SNARE Protein Required for Vision.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wallace B ThoresonDepartments of Ophthalmology & Visual Sciences and Pharmacology & Experimental Neuroscience, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA; email: wbthores@unmc.edu.
David ZenisekDepartments of Cellular and Molecular Physiology, Ophthalmology and Visual Sciences, and Neuroscience, Yale University, New Haven, Connecticut, USA; email: david.zenisek@yale.edu.

Funding

Regulation of Photoreceptor NeurotransmisssionR01EY010542 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KARATEKIN, ERDEM, THORESON, WALLACE B · 2001 to 2023
$7.7M
Mechanisms of the calcium-triggered neurotransmitter release machinery in hair cellsR01DC019057 · NIDCD · YALE UNIVERSITY · PI KARATEKIN, ERDEM, ZENISEK, DAVID PAUL · 2020 to 2024
$2.7M
Synaptic transmission at retinal ribbon synapsesR01EY032396 · NEI · YALE UNIVERSITY · PI THORESON, WALLACE B, ZENISEK, DAVID PAUL · 2021 to 2024
$1.9M
CHLORIDE REGULATION OF PHOTORECEPTOR NEUROTRANSMISSIONR29EY010542 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THORESON, WALLACE B · 1996 to 2000
$105k
NEI NIH HHS R01 EY010542NEI NIH HHS R01 EY032396NEI NIH HHS R29 EY010542NIDCD NIH HHS R01 DC019057
6 · The paper itself

Abstract

The sense of vision begins in the retina, where light is detected and processed through a complex series of synaptic connections into meaningful information relayed to the brain via retinal ganglion cells. Light responses begin as tonic and graded signals in photoreceptors, later emerging from the retina as a series of spikes from ganglion cells. Processing by the retina extracts critical features of the visual world, including spatial frequency, temporal frequency, motion direction, color, contrast, and luminance. To achieve this, the retina has evolved specialized and unique synapse types. These include the ribbon synapses of photoreceptors and bipolar cells, the dendritic synapses of amacrine and horizontal cells, and unconventional synaptic feedback from horizontal cells to photoreceptors. We review these unique synapses in the retina with a focus on the presynaptic molecules and physiological properties that shape their capabilities.

Indexed as

Presynaptic TerminalsRetinaSynapsesVision, OcularAnimalsHumansPhotoreceptor Cells, VertebrateRetinal Ganglion CellsVisual Pathwaysamacrine cellsbipolar cellshorizontal cellsphotoreceptor cellsretinal ribbon synapsesynaptic proteins

Identifiers

PMID38621251
PMCPMC11536687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.