Evidence map›Paper›PMID 38621210›Full record

ArticleZebrafish2024

A 3D-Printed and Freely Available Device to Measure the Zebrafish Optokinetic Response Before and After Injury.

Ashley Hermans, Sophia Tajnai, Allison Tieman, Sarah Young, Ashley Franklin, Mackenzie Horutz, Steven J Henle

Open access · greenAbstract read
In one paragraph

Article in Zebrafish, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ashley HermansCarthage College, Kenosha, Wisconsin, USA.
Sophia TajnaiCarthage College, Kenosha, Wisconsin, USA.
Allison TiemanCarthage College, Kenosha, Wisconsin, USA.
Sarah YoungCarthage College, Kenosha, Wisconsin, USA.
Ashley FranklinCarthage College, Kenosha, Wisconsin, USA.
Mackenzie HorutzCarthage College, Kenosha, Wisconsin, USA.
Steven J HenleCarthage College, Kenosha, Wisconsin, USA.ORCID 0000-0002-8007-1030
Carthage College · US

Funding

Cytoskeletal regulation and Yap/Taz activity in differentiating retinal neuronsR00EY027467 · NEI · CARTHAGE COLLEGE · PI HENLE, STEVEN J · 2018 to 2020
$746k
NIH NEI R00EY027467
6 · The paper itself

Abstract

Zebrafish eyes are anatomically similar to humans and have a higher percentage of cone photoreceptors more akin to humans than most rodent models, making them a beneficial model organism for studying vision. However, zebrafish are different in that they can regenerate their optic nerve after injury, which most other animals cannot. Vision in zebrafish and many other vertebrate animals, including humans, can be accessed using the optokinetic response (OKR), which is an innate eye movement that occurs when tracking an object. Because fish cannot use an eye chart, we utilize the OKR that is present in virtually all vertebrates to determine if a zebrafish has vision. To this end, we have developed an inexpensive OKR setup that uses 3D-printed and off-the-shelf parts. This setup has been designed and used by undergraduate researchers and is also scalable to a classroom laboratory setup. We demonstrate that this setup is fully functional for assessing the OKR, and we use it to illustrate the return of the OKR following optic nerve injury in adult zebrafish.

Indexed as

Nystagmus, OptokineticZebrafishAnimalsEyeHumansPrinting, Three-DimensionalneuroscienceOKRoptic nerveoptokinetic responseregenerationvision

Identifiers

PMID38621210
PMCPMC11035845
OpenAlexW4394853612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.