Evidence map›Paper›PMID 38621137›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.

Hozaifa Metwally, Maha M Elbrashy, Tatsuhiko Ozawa, Kazuki Okuyama, Jason T White, Janyerkye Tulyeu, Jonas Nørskov Søndergaard, James Badger Wing, Arisa Muratsu, Hisatake Matsumoto and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Threonine phosphorylation of STAT1 safeguards gut epithelial integrity and restricts interferon-mediated cytotoxicity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
  9. Transcriptional control of interferon-stimulated genes.The Journal of biological chemistry · 2024
    Review
  10. Article
  11. Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Hozaifa MetwallyLaboratory of Immune Regulation, The World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0002-8664-096X
Maha M ElbrashyLaboratory of Immune Regulation, The World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
Tatsuhiko OzawaDepartment of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-3112-452X
Kazuki OkuyamaLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Jason T WhiteLaboratory of Experimental Immunology, The World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
Janyerkye TulyeuHuman Immunology Team, Center for Infectious Disease Education and Research, Osaka University, Suita 565-0871, Japan.ORCID 0000-0003-1473-5561
Jonas Nørskov SøndergaardHuman Immunology Team, Center for Infectious Disease Education and Research, Osaka University, Suita 565-0871, Japan.ORCID 0000-0002-4438-6756
James Badger WingLaboratory of Human Single Cell Immunology, The World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0002-3462-1003
Arisa MuratsuDepartment of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Hisatake MatsumotoDepartment of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Masahito IkawaResearch Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0001-9859-6217
Hiroyuki KishiDepartment of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-8740-5371
Ichiro TaniuchiLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.ORCID 0000-0002-9853-9068
Tadamitsu KishimotoLaboratory of Immune Regulation, The World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
Osaka International University · JPThe University of Osaka · JPRIKEN Center for Integrative Medical Sciences · JPUniversity of Toyama · JP

Funding

Chugai PharmaceuticalsImmunology Frontier Research Center, Osaka UniversityKishimoto FoundationMinistry of Higher Education of the Arab Republic of Egypt
6 · The paper itself

Abstract

Since its discovery over three decades ago, signal transducer and activator of transcription 1 (STAT1) has been extensively studied as a central mediator for interferons (IFNs) signaling and antiviral defense. Here, using genetic and biochemical assays, we unveil Thr

Indexed as

LipopolysaccharidesSignal TransductionAnimalsInflammationInterferonsMicePhosphorylationSTAT1 Transcription FactorInterferonsLipopolysaccharidesSTAT1 Transcription FactorcytokinesphosphorylationsepsisStat1threonine

Identifiers

PMID38621137
PMCPMC11046697
OpenAlexW4394822519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.