ReviewNeurology perspectives2021
Persistent headache after COVID-19: Pathophysioloy, clinic and treatment.
Review in Neurology perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Post-COVID-19 headache- NDPH phenotype: a systematic review of case reports.Frontiers in pain research (Lausanne, Switzerland) · 2024Pooled it
- Clinical Manifestations Associated with Pain in Nursing Students in Emerging Adulthood with Long COVID.Nursing reports (Pavia, Italy) · 2026Article
- Clinical Practice Guideline Recommendations for Post-Acute Sequelae of COVID-19.Infection & chemotherapy · 2025Review
- Exploring Alice in Wonderland syndrome in adults with persistent headache after COVID-19: a cross-sectional study in Latin America.BMC neurology · 2025Article
- Long-Term Persistent Headache After SARS-CoV-2 Infection: A Follow-Up Population-Based Study.European journal of neurology · 2025Article
- Updated Clinical Practice Guidelines for the Diagnosis and Management of Long COVID.Infection & chemotherapy · 2024Review
- Current update on the neurological manifestations of long COVID: more questions than answers.EXCLI journal · 2024Review
- Understanding Post-COVID-19: Mechanisms, Neurological Complications, Current Treatments, and Emerging Therapies.International journal of general medicine · 2024Article
- Neurological and Psychiatric Manifestations of Post-COVID-19 Conditions.Journal of Korean medical science · 2023Article
- Italian good practice recommendations on management of persons with Long-COVID.Frontiers in public health · 2023Article
- Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients.Frontiers in neuroscience · 2023Article
- Preliminary Guidelines for the Clinical Evaluation and Management of Long COVID.Infection & chemotherapy · 2022Review
- Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case-control study.The journal of headache and pain · 2022Article
- Long COVID headache.The journal of headache and pain · 2022Review
- Post-acute sequelae of COVID-19 (PASC): a meta-narrative review of pathophysiology, prevalence, and management.SN comprehensive clinical medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The acute infection is characterised not only by respiratory symptoms, but also by multiple systemic manifestations, including neurological symptoms. Among these, headache is a frequent complaint. As the pandemic progresses and the population of patients recovering from COVID-19 grows, it is becoming apparent that the headache present in the acute stage of the infection may persist for an indeterminate period, becoming a major problem for the patient and potentially leading to disability. In this review we describe the pathophysiological and clinical aspects of persistent headache after COVID-19 based on the information currently available in the literature and the authors' clinical experience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.