ArticleProceedings of the National Academy of Sciences of the United States of America1985
Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Alpha-spectrin immunoanalog in Acanthamoeba cells.Histochemistry · 1990Article
- The complete sequence of Drosophila alpha-spectrin: conservation of structural domains between alpha-spectrins and alpha-actinin.The Journal of cell biology · 1989Article
- Neuraxin, a novel putative structural protein of the rat central nervous system that is immunologically related to microtubule-associated protein 5.The EMBO journal · 1989Article
- Primary structure of the brain alpha-spectrin.The Journal of cell biology · 1989Article
- Regulation of erythroid cell-specific gene expression during erythropoiesis.The British journal of cancer. Supplement · 1988Review
- Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species.Molecular and cellular biology · 1988Article
- Isolation and characterization of cDNA clones for human erythrocyte beta-spectrin.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
- Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins.The Journal of cell biology · 1987Article
- Beta spectrin bestows protein 4.1 sensitivity on spectrin-actin interactions.The Journal of cell biology · 1987Article
- Cloning of a portion of the chromosomal gene for human erythrocyte alpha-spectrin by using a synthetic gene fragment.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Increased concentration of spectrin is observed in avian dystrophic muscle.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A cDNA clone for nonerythroid alpha-spectrin was identified by direct immunological screening of a chicken smooth muscle cDNA library. A library prepared in the expression plasmids pUC8 and pUC9 was screened with an antiserum specific for chicken alpha-spectrin. Blots of poly(A)+ RNA from various tissues of chicken and mouse show that the cDNA hybridizes to an 8-kilobase mRNA. The cDNA hybridizes to a single-copy sequence on Southern blots of chicken genomic DNA. The complete nucleic acid sequence of the clone has a single 1419-base open reading frame. The derived amino acid sequence is organized into two partial and three complete 106-amino-acid repeats that show homology to the repeats described for human erythroid alpha- and beta-spectrin. Immunological and biochemical data indicate that chicken nonerythroid and human erythroid alpha-spectrin are two of the more widely diverged members of the spectrin family of proteins. In this respect, the degree of homology found between them was unexpected. Our data suggest a common evolutionary origin for these two alpha-spectrins and allow some predictions concerning spectrin gene structure.
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