Evidence map›Paper›PMID 38620644›Full record

ArticleClinical immunology communications2021

Pfizer-biontech COVID-19 RNA vaccination induces phosphatidylserine autoantibodies, cryoglobulinemia, and digital necrosis in a patient with pre-existing autoimmunity.

Sandy Nasr, Sara Khalil, Bernard J Poiesz, Katalin Banki, Andras Perl

Erratum issuedOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Considerations on COVID-19 vaccination.Clinical immunology communications · 2023
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sandy NasrDepartment of Medicine, College of Medicine, State University of New York, 750 East Adams Street, Syracuse, NY 13210, United States.
Sara KhalilDepartment of Medicine, College of Medicine, State University of New York, 750 East Adams Street, Syracuse, NY 13210, United States.
Bernard J PoieszDepartment of Medicine, College of Medicine, State University of New York, 750 East Adams Street, Syracuse, NY 13210, United States.
Katalin BankiDepartment of Medicine, College of Medicine, State University of New York, 750 East Adams Street, Syracuse, NY 13210, United States.
Andras PerlDepartment of Medicine, College of Medicine, State University of New York, 750 East Adams Street, Syracuse, NY 13210, United States.
State University of New York · US

Funding

Metabolic Control of T-cell Lineage Specification in SLER01AI072648 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2008 to 2024
$6.1M
IMPACT OF HRES-1 ENDOGENOUS RETROVIRUS IN SLER01AI048079 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2000 to 2013
$2.7M
Endocytic Control of Autophagosome Formation in Lupus T cellsR01AI122176 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2016 to 2020
$2.0M
Treatment of SLE with N-acetylcysteineR01AT004332 · NCCIH · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2008 to 2011
$1.6M
Mitochondrial dysfunction in patients with SLER21AI061066 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2004 to 2004
$266k
Treatment of SLE with sirolimusR34AI141304 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2019 to 2019
$243k
NCCIH NIH HHS R01 AT004332NIAID NIH HHS R01 AI048079NIAID NIH HHS R01 AI072648NIAID NIH HHS R01 AI122176NIAID NIH HHS R21 AI061066NIAID NIH HHS R34 AI141304
6 · The paper itself

Abstract

We describe a 64-year-old Caucasian female with a history of Raynaud's disease, hand arthritis, photosensitivity, Sjogren's syndrome and leukocytoclastic vasculitis who presented with progressively worsening fingertip necrosis that began three days after receiving a first dose of Pfizer-BioNTech COVID-19 RNA vaccine. Our workup revealed cryoglobulinemia, hypocomplementemia, elevated antinuclear antibodies (ANA) and IgM antiphospholipid autoantibodies (aPL) directed against phosphatidylserine (aPL-PS), suggesting a diagnosis of systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The patient failed to develop anti-spike IgG antibodies up to two months following vaccination. Disease progression was halted by plasmapheresis, anticoagulation, and immune suppression. We conclude that the vaccine RNA moiety may induce SLE manifesting in APS, cryoglobulinemia, hypocomplementemia, and digital necrosis.

Indexed as

Antiphospholipid antibodyAntiphospholipid syndromeCryoglobulinemiaDigital necrosisPfizer–BioNTech COVID-19 RNA vaccinePhosphatidylserine antibodySystemic lupus erythematosusVasculitis

Identifiers

PMID38620644
PMCPMC8486180
OpenAlexW3203609772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.