Evidence map›Paper›PMID 38620600›Full record

ReviewJournal of liver transplantation

COVID-19 in liver transplant recipients.

Juliana Piedade, Gustavo Pereira

Open access · goldAbstract readReview
In one paragraph

Review in Journal of liver transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Juliana PiedadeGastroenterology and Hepatology Unit, Bonsucesso Federal Hospital, (Ministry of Health), Avenida Londres 616 (21041-030), 3rd floor, Bonsucesso, Rio de Janeiro, RJ, Brazil.
Gustavo PereiraGastroenterology and Hepatology Unit, Bonsucesso Federal Hospital, (Ministry of Health), Avenida Londres 616 (21041-030), 3rd floor, Bonsucesso, Rio de Janeiro, RJ, Brazil.
Estácio (Brazil) · BRHospital Geral de Bonsucesso · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19), an infection caused by severe acute respiratory syndrome coronavirus-type 2 (SARS-CoV-2), has emerged as a serious threat to public health. Liver transplant (LT) recipients may be at increased risk of acquisition of SARS-CoV-2 infection and higher morbidity and mortality due to constant contact with health-care services, the use of immunosuppressants and frequent comorbidities. In the first part of this review we discuss (1) the epidemiology and risk factors for SARS-CoV-2 infection in LT recipients; (2) the clinical and laboratory features of COVID-19 in this specific population, highlighting differences in presenting signs and symptoms with respect to general populations and (3) the natural history and prognostic factors in LT recipients hospitalized with COVID-19, with particular focus on the possible role of immunosuppression. Thereafter, we review the potential therapeutic options for COVID-19 treatment and prevention. Specifically, we give an overview of current practice in immunosuppressant regimen changes, showing the potential benefits of this strategy, and explore safety and efficacy issues of currently approved drugs in LT recipients. The last topic is dedicated to the potential benefits and pitfalls of vaccination.

Indexed as

ACE2, angiotensin-convertingCI, calcineurin inhibitorsCI, confidence intervalCOVID-19COVID-19 drug treatmentDILI, drug-induced liver injuryECMO, extracorporeal membrane oxygenationGI, gastrointestinalHR, hazard ratioICU, intensive care unitIL-6, interleukin-6Immunosuppressive agentsIS, immunosuppressionLiver transplantationLT, liver transplantMELD, Model for End-Stage Liver DiseaseMMF, mycophenolate mofetilOR, odds ratioRCT, randomized controlled trialSARS-CoV2, severe acute respiratory syndrome coronavirus 2SOT, solid organ transplantULN, upper limits of normalVaccinationWHO, World Health Organization

Identifiers

PMID38620600
PMCPMC8295494
OpenAlexW3186794643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.