ReviewTrends in anaesthesia & critical care2021
Insights into neurological dysfunction of critically ill COVID-19 patients.
Review in Trends in anaesthesia & critical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Blood Biomarkers as Prognostic Indicators for Neurological Injury in COVID-19 Patients: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Critical COVID-19 and neurological dysfunction - a direct comparative analysis between SARS-CoV-2 and other infectious pathogens.Revista Brasileira de terapia intensiva · 2022Trial
- Effect of awake prone position on diaphragmatic thickening fraction in patients assisted by noninvasive ventilation for hypoxemic acute respiratory failure related to novel coronavirus disease.Critical care (London, England) · 2021Trial
- Ventilatory response and delirium risk in hospitalised patients with acute hypoxia due to COVID-19.Scientific reports · 2025Article
- Neuroleptics used in critical COVID associated with moderate-severe dyspnea after hospital discharge.Scientific reports · 2025Article
- Reply to: Critical COVID-19 and neurological dysfunction - a direct comparative analysis between SARS-CoV-2 and other infectious pathogens.Critical care science · 2024Article
- A retrospective multicenter cohort study of the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.Thrombosis journal · 2023Article
- Different COVID-19 treatments' impact on hospital length of stay.European journal of medical research · 2023Article
- Association between COVID-19 and Postoperative Neurological Complications and Antipsychotic Medication Use after Cancer Surgery: A Retrospective Study.Journal of personalized medicine · 2023Article
- Low dose ultra-slow infusion thrombolytic therapy (LDUSITT) as an alternative option in a COVID-19 patient with free-floating right atrial thrombus: a case report and review of literature.Thrombosis journal · 2023Article
- Quality of Life in COVID-Related ARDS Patients One Year after Intensive Care Discharge (Odissea Study): A Multicenter Observational Study.Journal of clinical medicine · 2023Article
- Use of almitrine in spontaneously breathing patients with COVID-19 treated with high-flow nasal cannula oxygen therapy and with persistent hypoxemia.Respiratory research · 2023Article
- Pressure injury prevalence and characteristics in patients with COVID-19 admitted to acute inpatient rehabilitation unit.Frontiers in rehabilitation sciences · 2023Article
- Ischemic strokes in COVID-19: risk factors, obesity paradox, and distinction between trigger and causal association.Frontiers in neurology · 2023Article
- Quality of life 1 year after hospital discharge in unvaccinated pregnant women with COVID-19 respiratory symptoms: a prospective observational study (ODISSEA-PINK study).Frontiers in medicine · 2023Article
- Severe Recurrent COVID-Associated Pulmonary Aspergillosis: A Challenging Case.Healthcare (Basel, Switzerland) · 2022Article
- Correlation does not mean causation: Proofs of COVID-19 associated strokes!Brain hemorrhages · 2022Article
- Secondary Complications in COVID-19 Patients: A Case Series.Tomography (Ann Arbor, Mich.) · 2022Article
- Reply letter to "COVID-19 and Recurrent Status Epilepticus".Acta bio-medica : Atenei Parmensis · 2022Article
- Neurological disorders in COVID-19: a case of Acute Disseminated Encephalomyelitis in an adult patient.Acta bio-medica : Atenei Parmensis · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novel coronavirus spread rapidly around the world infecting millions of people. It was thus declared a pandemic. This new virus damages the lungs. In the most severe cases, it leads to acute respiratory failure that requires intensive care treatment. However, many clinical reports have listed different neurological symptoms, leading to increased interest in the neurological involvement of COVID-19. Various pathophysiological mechanisms have been proposed to explain these neurological aspects. Direct viral invasion of the nervous system, systemic cytokine storm and severe hypoxemia are key factors in the development of symptoms. Critically ill patients present several additional risk factors for nervous system damage. Reasons for these include deep sedation and extended muscular paralysis, bed rest for several days, and the inability to receive proper physical rehabilitation. After ICU treatment, COVID-19 patients generally require an extensive rehabilitation program. However, distancing restrictions mean that in many cases physiotherapists are unable to enter ICUs, delaying the process of rehabilitation. The role of telemedicine should be considered as an adjunctive tool in the rehabilitation of critically ill COVID-19 patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.