Evidence map›Paper›PMID 38620056›Full record

Trial reportThe Journal of urology2024

Prophylactic Use of Biologic Mesh in Ileal Conduit (PUBMIC): A Randomized Clinical Trial.

Hooman Djaladat, Alireza Ghoreifi, Tapas Tejura, Gus Miranda, Jie Cai, Farshad Sheybaee Moghaddam, Ileana Aldana, Rene Sotelo, Inderbir Gill, Sumeet Bhanvadia and 5 more

Registry-linked trialAbstract readRandomized Controlled TrialClinical Trial, Phase III
PubMed Publisher
In one paragraph

Trial report in The Journal of urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02439060 (Prevention of Parastomal Hernia Following Radical Cystectomy and Ileal Conduit Using Biologic Mesh), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02439060 nacompletednot on this map

Prevention of Parastomal Hernia Following Radical Cystectomy and Ileal Conduit Using Biologic Mesh: Randomized Clinical Trial

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2015 to 2024Enrolled156ConditionsBladder Carcinoma, HerniaArmsAcellular Cadaveric Dermal Matrix
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Prophylactic Mesh in Parastomal Hernia Prevention: Current Evidence.Journal of abdominal wall surgery : JAWS · 2025
    Review
  11. Round up.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Hooman DjaladatInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Alireza GhoreifiInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-7368-7240
Tapas TejuraRadiology Department, Keck School of Medicine, University of Southern California, Los Angeles, California.
Gus MirandaInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Jie CaiInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Farshad Sheybaee MoghaddamInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Ileana AldanaInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Rene SoteloInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Inderbir GillInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Sumeet BhanvadiaInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Anne SchuckmanInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Mihir DesaiInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Monish AronInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Siamak DaneshmandInstitute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Vinay DuddalwarRadiology Department, Keck School of Medicine, University of Southern California, Los Angeles, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe assessed the effect of prophylactic biologic mesh on parastomal hernia (PSH) development in patients undergoing cystectomy and ileal conduit (IC). MATERIALS AND

methodsThis phase 3, randomized, controlled trial (NCT02439060) included 146 patients who underwent cystectomy and IC at the University of Southern California between 2015 and 2021. Follow-ups were physical exam and CT every 4 to 6 months up to 2 years. Patients were randomized 1:1 to receive FlexHD prophylactic biological mesh using sublay intraperitoneal technique vs standard IC. The primary end point was time to radiological PSH, and secondary outcomes included clinical PSH with/without surgical intervention and mesh-related complications.

resultsThe 2 arms were similar in terms of baseline clinical features. All surgeries and mesh placements were performed without any intraoperative complications. Median operative time was 31 minutes longer in patients who received mesh, yet with no statistically significant difference (363 vs 332 minutes,

conclusionsImplementation of biologic mesh at the time of IC construction is safe without significant protective effects within 2 years following surgery.

Indexed as

CystectomySurgical MeshUrinary DiversionAgedFemaleFollow-Up StudiesHumansIncisional HerniaMaleMiddle AgedPostoperative ComplicationsProphylactic Surgical ProceduresUrinary Bladder Neoplasmsbladder cancercystectomyileal conduitparastomal herniaprophylactic mesh

Identifiers

PMID38620056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.