Evidence map›Paper›PMID 38619811›Full record

ReviewHormones (Athens, Greece)2024

When rare diseases crisscross within the same patient: von Hippel-Lindau and type 1 gastric neuroendocrine tumor.

Krystallenia I Alexandraki, Ariadni Spyroglou, Paraskevi Xekouki, Konstantinos I Bramis, Georgios Kyriakopoulos, Konstantinos Barkas, Ioannis S Papanikolaou, George Mastorakos, Manousos Konstadoulakis

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PubMed Full text at PMC Publisher
In one paragraph

Review in Hormones (Athens, Greece), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Krystallenia I Alexandraki2nd Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece. alexandrakik@gmail.com.ORCID http://orcid.org/0000-0003-2398-6768
Ariadni Spyroglou2nd Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Paraskevi XekoukiEndocrinology and Diabetes Clinic, University Hospital of Heraklion, University of Crete School of Medicine, Voutes, Heraklion Crete, Greece.
Konstantinos I Bramis2nd Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Georgios KyriakopoulosDepartment of Pathology, Evangelismos Hospital, Athens, Greece.
Konstantinos BarkasDepartment of Neurosurgery, General Hospital of Nikaia-Peiraia, Agios Panteleimon, Athens, Greece.
Ioannis S Papanikolaou2nd Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
George Mastorakos2nd Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Manousos Konstadoulakis2nd Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GREvangelismos Hospital · GRGeneral Hospital of Nikea · GRUniversity of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Von-Hippel-Lindau (VHL) is a genetic multisystem disorder characterized by visceral cysts and benign and malignant tumors in various organs. Herein, we present the case of a 23-year-old woman with VHL presenting with multiple gastric neuroendocrine neoplasms (gNENs) type 1 in the context of chronic autoimmune gastritis (CAG). Although gNENs are not acknowledged as a typical entity in VHL patients, in the present case, gNENs were composed of neoplastic cells with clear cytoplasm usually seen in tumors related to VHL disease. We additionally performed a literature review on the presence of neuroendocrine clear cell tumors and report on further cases of clear cell NENs. The present case illustrates that clear-cell transformation in gNENs may be due to the dual genetic background of the patient; the real oncogenic stimulus may be more closely related to CAG than to VHL disease accompanied by an interplay between neoplastic and autoimmune processes. Therefore, close monitoring of patients with clear cell NENs appears to be important before excluding VHL disease, even in the context of phenotypically unrelated diseases.

Indexed as

Neuroendocrine TumorsStomach Neoplasmsvon Hippel-Lindau DiseaseAutoimmune DiseasesFemaleGastritisHumansRare DiseasesYoung AdultChronic autoimmune gastritisClear cellsGastric neuroendocrine neoplasmVon-Hippel-Lindau

Identifiers

PMID38619811
PMCPMC11436398
OpenAlexW4394817514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.