Evidence map›Paper›PMID 38619735›Full record

ArticlePharmacological reports : PR2024

Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia.

Michael Ramon de Lima Conceição, Jorge Lucas Teixeira-Fonseca, Leisiane Pereira Marques, Diego Santos Souza, Fabiana da Silva Alcântara, Diego Jose Belato Orts, Danilo Roman-Campos

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Pharmacological reports : PR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06063538 (A Prospective Study Using Intra-Pericardial Amiodarone for the Prevention of Postoperative Atrial Fibrillation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06063538 early_phase1recruitingnot on this map

A Prospective Study Using Intra-Pericardial Amiodarone for the Prevention of Postoperative Atrial Fibrillation (POAF) in Patients Undergoing Cardiac Arterial Bypass Grafting and/or Valve Surgery

TypeinterventionalSponsorUniversity of ChicagoRan2024 to 2027Enrolled63ConditionsAtrial Fibrillation, Post-Op ComplicationArmsCardiaMend in Combination with Amiodarone
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michael Ramon de Lima ConceiçãoLaboratory of CardioBiology, Department of Biophysics, Paulista School of Medicine, Federal University of Sao Paulo Botucatu Street, 862, Biological Science Building, 7th floor,, São Paulo, Brazil.
Jorge Lucas Teixeira-FonsecaLaboratory of CardioBiology, Department of Biophysics, Paulista School of Medicine, Federal University of Sao Paulo Botucatu Street, 862, Biological Science Building, 7th floor,, São Paulo, Brazil.
Leisiane Pereira MarquesLaboratory of CardioBiology, Department of Biophysics, Paulista School of Medicine, Federal University of Sao Paulo Botucatu Street, 862, Biological Science Building, 7th floor,, São Paulo, Brazil.
Diego Santos SouzaDepartment of Physiology, Federal University of Sergipe, São Cristóvão, Brazil.
Fabiana da Silva AlcântaraLaboratory of CardioBiology, Department of Biophysics, Paulista School of Medicine, Federal University of Sao Paulo Botucatu Street, 862, Biological Science Building, 7th floor,, São Paulo, Brazil.
Diego Jose Belato OrtsLaboratory of CardioBiology, Department of Biophysics, Paulista School of Medicine, Federal University of Sao Paulo Botucatu Street, 862, Biological Science Building, 7th floor,, São Paulo, Brazil.
Danilo Roman-CamposLaboratory of CardioBiology, Department of Biophysics, Paulista School of Medicine, Federal University of Sao Paulo Botucatu Street, 862, Biological Science Building, 7th floor,, São Paulo, Brazil. drcampos@unifesp.br.ORCID http://orcid.org/0000-0002-2690-912X
Universidade Federal de São Paulo · BRUniversidade Federal de Sergipe · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304257/2020-6Conselho Nacional de Desenvolvimento Científico e Tecnológico 310112/2023-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/14133-1Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 2019/18918-0Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 2021/05584-7; 2020/14635-1Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 2021/15122-0Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 2022/07256-0
6 · The paper itself

Abstract

backgroundAmiodarone (AMIO) is an antiarrhythmic drug with the pKa in the physiological range. Here, we explored how mild extracellular pH (pHe) changes shape the interaction of AMIO with atrial tissue and impact its pharmacological properties in the classical model of sea anemone sodium channel neurotoxin type 2 (ATX) induced late sodium current (I

methodIsolated atrial cardiomyocytes from male Wistar rats and human embryonic kidney cells expressing SCN5A Na

resultsA more acidophilic pHe caused negative inotropic effects on isolated RA and LA atrial tissue, without modification of the pharmacological properties of AMIO. A pHe of 7.0 changed the sodium current (I

conclusionThe pharmacological properties of AMIO concerning healthy rat atrial tissue are not dependent on pHe. However, the prevention of arrhythmias induced by I

Indexed as

Action PotentialsAmiodaroneAnti-Arrhythmia AgentsArrhythmias, CardiacHeart AtriaMyocytes, CardiacRats, WistarAnimalsCnidarian VenomsHEK293 CellsHumansHydrogen-Ion ConcentrationMaleNAV1.5 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesRatsAmiodaroneAnti-Arrhythmia AgentsCnidarian VenomsNAV1.5 Voltage-Gated Sodium ChannelSodiumtoxin II (Anemonia sulcata)AcidosisAmiodaroneAtrial arrhythmiasATXCardiomyocyteSodium channel

Identifiers

PMID38619735
OpenAlexW4394818641

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.