ArticleActa oncologica (Stockholm, Sweden)2024
Primary splenic angiosarcoma: a case series of a rare oncological entity and diagnostic challenge.
Article in Acta oncologica (Stockholm, Sweden), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 3 citations in OpenAlex.
- Ametabolic FDG-PET in Splenic Angiosarcoma: A Diagnostic Challenge.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Primary splenic angiosarcoma presenting with unexplained anemia in a young adult: a case report.Journal of medical case reports · 2026Article
- Primary splenic angiosarcoma with diffuse intrasinusoidal hepatic metastasis mimicking lymphoma: a diagnostic challenge.Clinical journal of gastroenterology · 2026Article
- Case Report of Primary Splenic Angiosarcoma in a Young Patient: A Very Rare and Challenging Disease.Case reports in surgery · 2026Article
- Primary splenic angiosarcoma presenting with multiple bone destruction as the initial manifestation: a case report and narrative review.Frontiers in oncology · 2026Article
- Splenic angiosarcoma with hepatic and cardiac metastases: a case report and literature review.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePrimary angiosarcoma of the spleen (PAS), an exceptionally rare and aggressive neoplasm with high metastatic risk (70%-85%), is frequently diagnosed in an advanced or metastatic stage. It presents diagnostic challenges due to its nonspecific symptomatology and resemblance to benign vascular lesions in various imaging modalities. PATIENTS AND
methodsThis case series aims to clarify the diagnostic difficulties by comparing imaging characteristics (CT-scan, MRI, and [18F]FDG-PET/CT) as well as pathological findings of three PAS cases diagnosed in different stages of the diseases (localized, metastatic, and metastatic with organ failure). Furthermore, a brief review on diagnostic and therapeutic features is included. RESULTS AND
interpretationWe suggest [18F]FDG-PET/CT as a differentiating tool between benign and malignant splenic lesions and propose a flowchart of a diagnostic algorithm for PAS. For treatment, we advocate for early splenectomy and when systemic therapy is warranted, paclitaxel emerges as a viable first-line option. While it is crucial to acknowledge that further trial data is required to evaluate the efficacy of emerging treatment regimens, designing and conducting trials for PAS is challenging given its scarcity and aggressive behavior. Therefore case reporting remains important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.