Article in Journal of immunology (Baltimore, Md. : 1950), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 1 institution in 1 country.
J Michael StolleyDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; and Center for Immunology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-4321-6413
Milcah C ScottDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; and Center for Immunology, University of Minnesota, Minneapolis, MN.ORCID 0000-0003-2151-7335
Stephen D O'FlanaganDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; and Center for Immunology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-9286-1208
Marco KünzliDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; and Center for Immunology, University of Minnesota, Minneapolis, MN.
Courtney A MatsonDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; and Center for Immunology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-9817-4986
Eyob WeyuDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; and Center for Immunology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-1755-0354
Ryan A LangloisDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; and Center for Immunology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-0515-571X
Vaiva VezysDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; and Center for Immunology, University of Minnesota, Minneapolis, MN.
David MasopustDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN; and Center for Immunology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-9440-3884
University of Minnesota · US
Funding
COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
Mucosal T Cell Memory to PathogensR01AI084913 · NIAID · UNIVERSITY OF MINNESOTA · PI MASOPUST, DAVID · 2010 to 2023
$5.8M
Resident Memory T CellsR01AI146032 · NIAID · UNIVERSITY OF MINNESOTA · PI DAVID MASOPUST · 2020 to 2026
$3.8M
New mouse model to better predict human immunity to influenza vaccination and infectionR01AI150600 · NIAID · UNIVERSITY OF MINNESOTA · PI LANGLOIS, RYAN, MASOPUST, DAVID · 2021 to 2024
$2.5M
Mucosal T cell memory to pathogensR37AI084913 · NIAID · UNIVERSITY OF MINNESOTA · PI DAVID MASOPUST · 2024 to 2026
$1.7M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI150600HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) R01AI084913HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) R01AI146032NIAID NIH HHS 75N93019C00051NIAID NIH HHS R01 AI084913NIAID NIH HHS R01 AI146032NIAID NIH HHS R01 AI150600
6 · The paper itself
Abstract
Humans experience frequent respiratory infections. Immunology and vaccinology studies in mice are typically performed in naive specific pathogen-free animals responding to their very first respiratory challenge. We found that the first respiratory infection induces lifelong enlargement of the lung-draining mediastinal lymph nodes (medLNs). Furthermore, infection-experienced medLNs supported better naive T cell surveillance and effector responses to new unrelated infections that exhibited more biased accumulation and memory establishment within the lung. Moreover, we observed that weight loss induced by influenza infection was substantially reduced in mice that had recovered from a previous unrelated respiratory viral challenge. These data show that the lack of infectious history and corresponding medLN hypoplasia in specific pathogen-free mice alter their immune response to lung infections. Preclinical vaccination and immunology studies should consider the previous infectious experience of the model organism.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Cutting Edge: First Lung Infection Permanently Enlarges Lymph Nodes and Enhances New T Cell Responses. · full record | OpenQuestion