Evidence map›Paper›PMID 38619236›Full record

ArticlemBio2024

A ketogenic diet enhances fluconazole efficacy in murine models of systemic fungal infection.

Julia R Palmucci, Blake E Sells, Charles D Giamberardino, Dena L Toffaletti, Baodi Dai, Yohannes G Asfaw, Laura G Dubois, Zhong Li, Barbara Theriot, Wiley A Schell and 3 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Cryptococcal nutrient acquisition and pathogenesis: dining on the host.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Julia R Palmucci *Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-6343-8278
Blake E Sells *Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Charles D GiamberardinoDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7813-5616
Dena L ToffalettiDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Baodi DaiDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Yohannes G AsfawDepartment of Laboratory Animal Resources, Duke University Medical Center, Durham, North Carolina, USA.
Laura G DuboisDuke Proteomics and Metabolomics Core Facility, Duke University, Durham, North Carolina, USA.
Zhong LiDuke Proteomics and Metabolomics Core Facility, Duke University, Durham, North Carolina, USA.
Barbara TheriotDepartment of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Wiley A SchellDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
William HopeAntimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.
Jennifer L TenorDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
John R PerfectDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-8742-3676
Duke University · USDuke Medical Center · USUniversity of Liverpool · GB

Funding

Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
Pathobiology of C. neoformans in the Central Nervous SystemR01AI073896 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2008 to 2018
$4.4M
Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDSR01AI093257 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2011 to 2022
$3.8M
NIAID NIH HHS R01 AI073896NIAID NIH HHS R01 AI093257NIAID NIH HHS UC6 AI058607
6 · The paper itself

Abstract

Invasive fungal infections are a significant public health concern, with mortality rates ranging from 20% to 85% despite current treatments. Therefore, we examined whether a ketogenic diet could serve as a successful treatment intervention in murine models of

Indexed as

Antifungal AgentsCandida albicansCandidiasisCryptococcosisCryptococcus neoformansDiet, KetogenicDisease Models, AnimalFluconazoleAnimalsBrainFemaleLungMiceAntifungal AgentsFluconazoleCandidacryptococcal meningitisCryptococcusfluconazoleketogenic diet

Identifiers

PMID38619236
PMCPMC11077957
OpenAlexW4394808638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.