Evidence map›Paper›PMID 38618723›Full record

ReviewCirculation2024

Environmental Exposures and Pediatric Cardiology: A Scientific Statement From the American Heart Association.

Justin P Zachariah, Pei-Ni Jone, Andrew O Agbaje, Heather H Ryan, Leonardo Trasande, Wei Perng, Shohreh F Farzan, American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Lifestyle and Cardiometabolic Health; and Council on Clinical Cardiology

Abstract readReview
In one paragraph

Review in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Redlining, Urban Heat, and Climate Hazards: Impacts on Children's Cardiometabolic Health.Journal of urban health : bulletin of the New York Academy of Medicine · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Current hypertension epidemiology and contemporary approaches using the "Real-World Evidence Cycle" framework.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  8. Article
  9. Observational
  10. Review
  11. Short-term exposure to CO and NOFrontiers in public health · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. New avenues in childhood vasculitis.Pediatric rheumatology online journal · 2025
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Epigenetic Consequences of In Utero PFAS Exposure: Implications for Development and Long-Term Health.International journal of environmental research and public health · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Justin P Zachariah
Pei-Ni Jone
Andrew O Agbaje
Heather H Ryan
Leonardo Trasande
Wei Perng
Shohreh F Farzan
American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Lifestyle and Cardiometabolic Health; and Council on Clinical Cardiology

Funding

The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Early Life Stress and the Environmental Origins of Disease: a Population-based Prospective Longitudinal Study of Children in Rural Poverty (ECHO)UH3OD023332 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KOPP, LISA MICHELLE, SWINGLER, MARGARET M. · 2018 to 2022
$22.7M
Project 3: Maternal Exposure to Environmental Hazards and Psychosocial Stressors and Postpartum Allostatic LoadP50MD015705 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2020 to 2024
$8.1M
Developmental Origins of Kidney Function in Early Life and Environmental RisksR01ES032214 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MALAGA-DIEGUEZ, LAURA, TRASANDE, LEONARDO · 2020 to 2024
$3.5M
The Salton Sea and Children's Health: Assessing Imperial Valley Respiratory Health and the EnvironmentR01ES029598 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FARZAN, SHOHREH F, JOHNSTON, JILL E · 2018 to 2022
$3.3M
Air pollutant exposure and progression of subclinical atherosclerosis during the critical transition from childhood to adulthoodR01ES031590 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FARZAN, SHOHREH F · 2021 to 2025
$2.9M
Preconceptual Bisphenol and Phthalate Effects on Early Embryonic DevelopmentR01ES029779 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2018 to 2023
$2.7M
Causal mechanisms in adolescent arterial stiffnessR01HL148217 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI ZACHARIAH, JUSTIN P.V. · 2019 to 2023
$2.0M
NHLBI NIH HHS R01 HL148217NIEHS NIH HHS R01 ES029598NIEHS NIH HHS R01 ES029779NIEHS NIH HHS R01 ES031590NIEHS NIH HHS R01 ES032214NIH HHS UH3 OD023287NIH HHS UH3 OD023305NIH HHS UH3 OD023332NIMHD NIH HHS P50 MD015705NIOSH CDC HHS U01 OH012472
6 · The paper itself

Abstract

Environmental toxicants and pollutants are causes of adverse health consequences, including well-established associations between environmental exposures and cardiovascular diseases. Environmental degradation is widely prevalent and has a long latency period between exposure and health outcome, potentially placing a large number of individuals at risk of these health consequences. Emerging evidence suggests that environmental exposures in early life may be key risk factors for cardiovascular conditions across the life span. Children are a particularly sensitive population for the detrimental effects of environmental toxicants and pollutants given the long-term cumulative effects of early-life exposures on health outcomes, including congenital heart disease, acquired cardiac diseases, and accumulation of cardiovascular disease risk factors. This scientific statement highlights representative examples for each of these cardiovascular disease subtypes and their determinants, focusing specifically on the associations between climate change and congenital heart disease, airborne particulate matter and Kawasaki disease, blood lead levels and blood pressure, and endocrine-disrupting chemicals with cardiometabolic risk factors. Because children are particularly dependent on their caregivers to address their health concerns, this scientific statement highlights the need for clinicians, research scientists, and policymakers to focus more on the linkages of environmental exposures with cardiovascular conditions in children and adolescents.

Indexed as

American Heart AssociationCardiovascular DiseasesEnvironmental ExposureAdolescentCardiologyChildEnvironmental PollutantsHumansRisk FactorsUnited StatesEnvironmental PollutantsAHA Scientific Statementsendocrine disruptorsenvironmental pollutantsheart defects, congenitalheart disease risk factorsmetals, heavymucocutaneous lymph node syndrome

Identifiers

PMID38618723
PMCPMC12312003

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.