Evidence map›Paper›PMID 38618242›Full record

ArticleJournal of pharmaceutical analysis2024

Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping.

Ding-Jun Hao, Yue Qin, Shi-Jie Zhou, Bu-Huai Dong, Jun-Song Yang, Peng Zou, Li-Ping Wang, Yuan-Ting Zhao

Open access · goldAbstract read
In one paragraph

Article in Journal of pharmaceutical analysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ding-Jun HaoDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Yue QinDepartment of Anesthesiology, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Shi-Jie ZhouState Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Bu-Huai DongDepartment of Anesthesiology, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Jun-Song YangDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Peng ZouDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Li-Ping WangDepartment of Cardiovascular Medicine, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Yuan-Ting ZhaoDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Xi'an Jiaotong University · CNXi'an Honghui Hospital · CNState Key Laboratory of Biotherapy

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyaluronan and proteoglycan link protein 1 (Hapln1) supports active cardiomyogenesis in zebrafish hearts, but its regulation in mammal cardiomyocytes is unclear. This study aimed to explore the potential regulation of Hapln1 in the dedifferentiation and proliferation of cardiomyocytes and its therapeutic value in myocardial infarction with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) and an adult mouse model of myocardial infarction. HiPSC-CMs and adult mice with myocardial infarction were used as

Indexed as

Cardiomyocyte proliferationGDF11Hapln1iPSC-CMsVersican

Identifiers

PMID38618242
PMCPMC11010450
OpenAlexW4386965609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.