ReviewSpine surgery and related research2024
Postoperative Epidural Fibrosis: Challenges and Opportunities - A Review.
Review in Spine surgery and related research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 23 citations in OpenAlex.
- Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives.Iranian journal of medical sciences · 2026Review
- Predictors of Treatment Success Following Pulsed Radiofrequency of the Lumbar Dorsal Root Ganglion: A Multivariable Prediction Model with Clinical Nomogram.Current pain and headache reports · 2026Review
- Piezo1 drives fibroblast activation in epidural fibrotic remodelling via the ET-1/HIF-1α pathway.Bone & joint research · 2026Article
- Ginsenoside Rg1 mitigates epidural fibrosis after laminectomy in rats: histopathological, TUNEL, and transcriptional evidence.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Nintedanib Attenuates Epidural Fibrosis after Laminectomy in Rats.Journal of Korean Neurosurgical Society · 2026Article
- Bispecific antibody engineered extracellular vesicles redirect T cells to prevent postoperative epidural fibrosis.Nature communications · 2026Article
- Long-Term Clinical Outcomes After Ultrasound-Guided Cervical Retrolaminar Block in Patients with Cervical Radiculopathy.Journal of clinical medicine · 2026Article
- Comparing Unilateral Biportal Endoscopic Discectomy Versus Microdiscectomy for Lumbar Disc Herniation: A Systematic Review and Meta-Analysis.Global spine journal · 2026Review
- Ligamentum flavum preservation via unilateral biportal endoscopy in lumbar discectomy: a "Door-Opening" technique and its clinical outcomes.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Experimental evaluation of femoral vein grafts and platelet-rich fibrin for reducing epidural fibrosis in a rat laminectomy model.Scientific reports · 2026Article
- Review
- The Incidence, Grading, and Treatment of Spinal Epidural Hematoma After Cervical Laminoplasty: A Retrospective Study Based on Postoperative MRI of 207 Patients.Global spine journal · 2026Article
- Clinical Insights and Statistical Analysis of Failed Back Surgery Syndrome: A Multicentric Retrospective Review.Asian journal of neurosurgery · 2026Article
- Revision surgical treatments and classification system for cage retropulsion in degenerative lumbar disease.BMC musculoskeletal disorders · 2026Article
- Case Report: Feline spinous process giant-cell osteosarcoma.Frontiers in veterinary science · 2026Article
- Article
- The augmentative role of chitosan and platelet-rich fibrin in reducing epidural fibrosis after laminectomy in rats.European journal of medical research · 2025Article
- Article
- The Preoperative Level of Pain Predicts Chronic Pain in Patients Operated on for Degenerative Disc Disease-A Prospective Study.Journal of clinical medicine · 2025Article
- Progress in Polysaccharide-Based Hydrogels for Preventing Postoperative Adhesions: A Review.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative epidural fibrosis (EF) is still a major limitation to the success of spine surgery. Fibrotic adhesions in the epidural space, initiated via local trauma and inflammation, can induce difficult-to-treat pain and constitute the main cause of failed back surgery syndrome, which not uncommonly requires operative revision. Manifold agents and methods have been tested for EF relief in order to mitigate this longstanding health burden and its socioeconomic consequences. Although several promising strategies could be identified, few have thus far overcome the high translational hurdle, and there has been little change in standard clinical practice. Nonetheless, notable research progress in the field has put new exciting avenues on the horizon. In this review, we outline the etiology and pathogenesis of EF, portray its clinical and surgical presentation, and critically appraise current efforts and novel approaches toward enhanced prevention and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.