Evidence map›Paper›PMID 38618176›Full record

ArticleBio-protocol2024

Purification of Native Dentilisin Complex from

Pachiyappan Kamarajan, John C Timm, M Paula Goetting-Minesky, Erin T Malone, Sean Ganther, Allan Radaic, Christian Tafolla, J Christopher Fenno, Yvonne L Kapila

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bio-protocol, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Clinical characteristics ofFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pachiyappan KamarajanDepartment of Biosystems and Function, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
John C TimmDepartment of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
M Paula Goetting-MineskyDepartment of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Erin T MaloneDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.
Sean GantherDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.
Allan RadaicDepartment of Biosystems and Function, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
Christian TafollaDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, USA.
J Christopher FennoDepartment of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Yvonne L KapilaDepartment of Biosystems and Function, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
University of California, San Francisco · USUniversity of Michigan–Ann Arbor · US

Funding

UCSF INTEGRATED DDS-PHD TRAINING PROGRAMT32DE007306 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yukiko Nakano · 1996 to 2026
$15.4M
Treponema - Host Cell and Tissue InteractionsR01DE025225 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI J CHRISTOPHER FENNO, Yvonne L Kapila · 2015 to 2026
$6.3M
Surface protein complexes of oral treponemes: assembly and host cell interactionsR01DE018221 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FENNO, J CHRISTOPHER · 2009 to 2010
$752k
Characterization of Treponema Denticola-Mediated Interactions With Periodontal Ligament Cells Leading to Persistent Host Cell/Tissue DestructionF30DE027598 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALONE, ERIN TRENT · 2017 to 2022
$280k
NIDCR NIH HHS F30 DE027598NIDCR NIH HHS R01 DE018221NIDCR NIH HHS R01 DE025225NIDCR NIH HHS T32 DE007306
6 · The paper itself

Abstract

Periodontal disease is characterized by the destruction of the hard and soft tissues comprising the periodontium. This destruction translates to a degradation of the extracellular matrices (ECM), mediated by bacterial proteases, host-derived matrix metalloproteinases (MMPs), and other proteases released by host tissues and immune cells. Bacterial pathogens interact with host tissue, triggering adverse cellular functions, including a heightened immune response, tissue destruction, and tissue migration. The oral spirochete

Indexed as

DentilisinGelatin zymographyMatrix metalloproteinasesMMP-2Periodontal ligament (PDL)Treponema denticola

Identifiers

PMID38618176
PMCPMC11006804
OpenAlexW4394820196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.