Evidence map›Paper›PMID 38617592›Full record

ArticleNeurophotonics2024

Neurophotonics beyond the surface: unmasking the brain's complexity exploiting optical scattering.

Fei Xia, Caio Vaz Rimoli, Walther Akemann, Cathie Ventalon, Laurent Bourdieu, Sylvain Gigan, Hilton B de Aguiar

Abstract read
In one paragraph

Article in Neurophotonics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Fei XiaSorbonne Université, Collège de France, Laboratoire Kastler Brossel, ENS-Université PSL, CNRS, Paris, France.ORCID https://orcid.org/0000-0001-6591-8769
Caio Vaz RimoliSorbonne Université, Collège de France, Laboratoire Kastler Brossel, ENS-Université PSL, CNRS, Paris, France.ORCID https://orcid.org/0000-0002-2457-4303
Walther AkemannUniversité PSL, Institut de Biologie de l'ENS, École Normale Supérieure, CNRS, INSERM, Paris, France.ORCID https://orcid.org/0000-0002-4978-4665
Cathie VentalonUniversité PSL, Institut de Biologie de l'ENS, École Normale Supérieure, CNRS, INSERM, Paris, France.ORCID https://orcid.org/0000-0001-8174-7840
Laurent BourdieuUniversité PSL, Institut de Biologie de l'ENS, École Normale Supérieure, CNRS, INSERM, Paris, France.ORCID https://orcid.org/0000-0003-0195-8758
Sylvain GiganSorbonne Université, Collège de France, Laboratoire Kastler Brossel, ENS-Université PSL, CNRS, Paris, France.ORCID https://orcid.org/0000-0002-9914-6231
Hilton B de AguiarSorbonne Université, Collège de France, Laboratoire Kastler Brossel, ENS-Université PSL, CNRS, Paris, France.ORCID https://orcid.org/0000-0002-2426-0371

Funding

Bringing laser focus to voltage imaging: Enhanced indicators and advanced scanning methods for two-photon recording of dense networks in vivoU01NS103464 · NINDS · STANFORD UNIVERSITY · PI DIEUDONNE, STEPHANE, LIN, MICHAEL Z. · 2017 to 2019
$2.9M
In vivo Imaging of Neuroactivity in the Deep Forward Scattering Regime Using Speckle Identification and Demixing (SPID) MicroscopyRF1NS113251 · NINDS · ROCKEFELLER UNIVERSITY · PI GIGAN, SYLVAIN, VAZIRI, ALIPASHA · 2019 to 2019
$2.1M
NINDS NIH HHS RF1 NS113251NINDS NIH HHS U01 NS103464
6 · The paper itself

Abstract

The intricate nature of the brain necessitates the application of advanced probing techniques to comprehensively study and understand its working mechanisms. Neurophotonics offers minimally invasive methods to probe the brain using optics at cellular and even molecular levels. However, multiple challenges persist, especially concerning imaging depth, field of view, speed, and biocompatibility. A major hindrance to solving these challenges in optics is the scattering nature of the brain. This perspective highlights the potential of complex media optics, a specialized area of study focused on light propagation in materials with intricate heterogeneous optical properties, in advancing and improving neuronal readouts for structural imaging and optical recordings of neuronal activity. Key strategies include wavefront shaping techniques and computational imaging and sensing techniques that exploit scattering properties for enhanced performance. We discuss the potential merger of the two fields as well as potential challenges and perspectives toward longer term

Indexed as

brain probingcomplex mediacomputational imagingneurophotonicswavefront shaping

Identifiers

PMID38617592
PMCPMC11014413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.