Article in Neurology. Clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04829656 (Identifying Factors Predicting ACcurately End-of-Life in Dementia With Lewy Bodies and Promoting Quality End-of-Life Experiences), which is not on this map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors at 1 institution in 2 countries.
Melissa J ArmstrongDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0002-2163-1907
Yunfeng DaiDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0003-3961-4766
Kaitlin SovichDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0002-4738-3307
Brian LaBarreDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0009-0001-6566-6861
Henry L PaulsonDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0002-0382-7535
Susan M MaixnerDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0002-8782-7435
Julie A FieldsDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0002-1282-9866
Angela M LundeDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0003-3315-9790
Leah K ForsbergDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0003-4086-9598
Bradley F BoeveDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0002-4153-8187
Carol A ManningDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0003-4205-2485
James E GalvinDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0001-5678-245X
Angela S TaylorDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0003-2001-3776
Zhigang LiDepartment of Neurology (MJA, KS), University of Florida College of Medicine; Norman Fixel Institute for Neurological Diseases (MJA); Department of Biostatistics (YD, BL, ZL), University of Florida College of Medicine, Gainesville; Departments of Neurology (HLP) and Psychiatry (SMM), University of Michigan, Ann Arbor; Departments of Psychiatry and Psychology (JAF) and Neurology (AML, LKF, BFB), Mayo Clinic Rochester, MN; Department of Neurology (CAM), University of Virginia, Charlottesville; Comprehensive Center for Brain Health (JEG), Department of Neurology, University of Miami Miller School of Medicine, FL; and Lewy Body Dementia Association (AST), Lilburn, GA.ORCID https://orcid.org/0000-0002-6224-1833
Mayo Clinic · US
Funding
Identifying Factors Predicting ACcurately End-of-Life in Dementia with Lewy Bodies and Promoting Quality End-of-Life Experiences: the PACE-DLB StudyR01AG068128 · NIA · UNIVERSITY OF FLORIDA · PI ARMSTRONG, MELISSA JO · 2020 to 2024
$3.4M
NIA NIH HHS R01 AG068128
6 · The paper itself
Abstract
Background and Objectives: Dementia with Lewy bodies (DLB) is a common degenerative dementia, but research on caregiver experiences in late stages is lacking. This study aimed to investigate the caregiving experience in moderate-advanced DLB to identify opportunities for improving care and support. Methods: Dyads of individuals with moderate-advanced DLB and their primary informal caregivers were recruited from specialty clinics, advocacy organizations, and research registries. The study collected demographics, disease-related measures, and measures of the caregiver experience relating to caregiver support, burden, grief, self-efficacy, depression, quality of life, and coping. Spearman correlation coefficients and Wilcoxon rank-sum tests evaluated the relationships of caregiver measures with patient and caregiver variables with adjustments for multiple testing. Results: Caregivers (n = 143) were mostly women (83.5%) and spouses (84.7%) (mean age 68 years; range 37-85). Almost 40% reported high burden and/or depression. Caregiver measures correlated with fluctuation and behavioral symptom severity, sleepiness, and autonomic symptoms of the person with DLB. Higher burden correlated with worse caregiver quality of life, higher depression, and grief. Greater self-efficacy, social support, and resilience correlated with lower caregiver burden. The most frequently reported caregiver concerns were being unable to plan for the future, having to put the needs of the person with DLB ahead of the caregiver's own needs, and worry that the person with DLB would become too dependent on the caregiver, but many additional concerns were endorsed. Caregivers were generally satisfied with medical team support. The lowest reported satisfaction related to information regarding disease progression and how well medical teams shared information with each other. Discussion: Various patient-related and caregiver-related factors influence caregiver experiences in moderate-advanced DLB. Clinicians can target caregiver needs by providing support resources and DLB education and treating bothersome patient symptoms. Future research should investigate what interventions can modify and improve caregiver experiences in advanced DLB and identify therapeutics for patient symptoms currently without adequate treatments (e.g., fluctuations, daytime sleepiness). Trial Registration Information: NCT04829656.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Caregiver Experiences and Burden in Moderate-Advanced Dementia With Lewy Bodies. · full record | OpenQuestion