Evidence map›Paper›PMID 38617360›Full record

ArticlebioRxiv : the preprint server for biology2024

APOBEC shapes tumor evolution and age at onset of lung cancer in smokers.

Tongwu Zhang, Jian Sang, Phuc H Hoang, Wei Zhao, Jennifer Rosenbaum, Kofi Ennu Johnson, Leszek J Klimczak, John McElderry, Alyssa Klein, Christopher Wirth and 21 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 12 institutions in 3 countries.

Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jian SangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Phuc H HoangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Wei ZhaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jennifer RosenbaumWestat, Rockville, MD, USA.
Kofi Ennu JohnsonNew York Genome Center, New York, USA.
Leszek J KlimczakIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
John McElderryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Alyssa KleinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Christopher WirthManchester Cancer Research Centre, The University of Manchester, Manchester, UK.
Erik N BergstromDepartment of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Marcos Díaz-GayDepartment of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Raviteja VangaraDepartment of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Frank Colon-MatosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Scott M LawrenceDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Nathan ColeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Teresa M PrzytyckaNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Robert HomerDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Angela C PesatoriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Dario ConsonniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Marcin ImielinskiNew York Genome Center, New York, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
David C WedgeManchester Cancer Research Centre, The University of Manchester, Manchester, UK.
Dmitry A GordeninGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Reuben S HarrisDepartment of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX, USA.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
National Cancer Institute · USUniversity of California San Diego · USFrederick National Laboratory for Cancer Research · USNational Institute of Environmental Health Sciences · USNew York Genome Center · USUniversity of Manchester · GBFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHoward Hughes Medical Institute · USNational Institutes of Health · USUniversity of Milan · ITWestat (United States) · USYale University · US

Funding

Studies of Genetic and Environmental EpidemiologyZIACP101231 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LANDI, MARIA · 2018 to 2025
$23.6M
Targeting Polθ to Overcome PARP Inhibitor Resistance in Homologous Recombination Deficient Breast CancerP50CA247749 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Sarat Chandarlapaty, Simon N. Powell · 2020 to 2026
$16.3M
PROJECT 3 – BIOLOGY OF DNA DEAMINASES IN CANCERP01CA234228 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Michael Allen Carpenter · 2019 to 2026
$14.5M
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4M
Mutational Signatures of a Combined Environmental Exposure: Arsenic and Ultraviolet RadiationR01ES030993 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI HUDSON, LAURIE G, LIU, KE JIAN · 2020 to 2024
$2.5M
Comprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2M
Intramural NIH HHS ZIA CP101231NCI NIH HHS P01 CA234228NCI NIH HHS P50 CA247749NCI NIH HHS R01 CA269919NIEHS NIH HHS R01 ES030993NIEHS NIH HHS R01 ES032547
6 · The paper itself

Abstract

APOBEC enzymes are part of the innate immunity and are responsible for restricting viruses and retroelements by deaminating cytosine residues

Identifiers

PMID38617360
PMCPMC11014539
OpenAlexW4393902110

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.