Evidence map›Paper›PMID 38617297›Full record

ArticlebioRxiv : the preprint server for biology2024

Airway injury induces alveolar epithelial and mesenchymal responses mediated by macrophages.

Irene G Wong, Jillian Stark, VanNashlee Ya, Aaron L Moye, Alan Baez Vazquez, Susanna M Dang, Andrea Shehaj, Maral J Rouhani, Roderick Bronson, Sam M Janes and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Irene G WongHarvard University, Cambridge, MA 02138, USA.ORCID 0000-0001-5229-2111
Jillian StarkStem Cell Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
VanNashlee YaStem Cell Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Aaron L MoyeStem Cell Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Alan Baez VazquezHarvard University, Cambridge, MA 02138, USA.
Susanna M DangHarvard University, Cambridge, MA 02138, USA.
Andrea ShehajStem Cell Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Maral J RouhaniUCL Respiratory, Division of Medicine, University College London, London, UK.
Roderick BronsonRodent Histopathology Core, Harvard Medical School, Boston, MA 02115, USA.
Sam M JanesUCL Respiratory, Division of Medicine, University College London, London, UK.
Samuel P RowbothamStem Cell Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Margherita PaschiniStem Cell Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Ruth A FranklinDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6563-6187
Carla F KimStem Cell Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Boston Children's Hospital · USHarvard University · USUniversity College London · GB

Funding

Cell-cell interactions governing lung epithelial progenitor cellsR35HL150876 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Carla F. Kim · 2020 to 2026
$6.2M
In Vivo and In Vitro Characterization of Bronchio-Alveolar Stem CellsR01HL090136 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KIM, CARLA F. · 2007 to 2010
$1.9M
Macrophage-mediated regulation of inflammation and tissue repairR35GM150816 · NIGMS · HARVARD MEDICAL SCHOOL · PI Ruth A Franklin · 2023 to 2026
$1.9M
Signaling pathways in lung stem cell differentiationR01HL125821 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KIM, CARLA F. · 2015 to 2018
$1.8M
Mechanisms of Thrombospondin-1 as a pulmonary vascular mediatorR01HL132266 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KIM, CARLA F. · 2017 to 2020
$1.6M
Macrophage-Mediated Lung Repair Programs Following InjuryF31HL172650 · NHLBI · HARVARD UNIVERSITY · PI Alan Baez Vazquez · 2024 to 2026
$113k
Investigating the effects of airway injury on the alveolar compartment of the lung.F31HL159919 · NHLBI · HARVARD MEDICAL SCHOOL · PI WONG, IRENE GAR-LING · 2021 to 2022
$68k
NHLBI NIH HHS F31 HL159919NHLBI NIH HHS F31 HL172650NHLBI NIH HHS R01 HL090136NHLBI NIH HHS R01 HL125821NHLBI NIH HHS R01 HL132266NHLBI NIH HHS R35 HL150876NIGMS NIH HHS R35 GM150816
6 · The paper itself

Abstract

Acute injury in the airways or the lung activates local progenitors and stimulates changes in cell-cell interactions to restore homeostasis, but it is not appreciated how more distant niches are impacted. We utilized mouse models of airway-specific epithelial injury to examine secondary tissue-wide alveolar, immune, and mesenchymal responses. Single-cell transcriptomics and

Identifiers

PMID38617297
PMCPMC11014629
OpenAlexW4393902036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.