ArticlebioRxiv : the preprint server for biology2024
Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaques.
Xiaoke Xu, Meng Niu, Benjamin G Lamberty, Katy Emanuel, Andrew J Trease, Mehnaz Tabassum, Jeffrey D Lifson, Howard S Fox
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors at 2 institutions in 1 country.
Xiaoke XuDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Meng NiuDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Benjamin G LambertyDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Katy EmanuelDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Andrew J TreaseDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Mehnaz TabassumDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Jeffrey D LifsonAIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, Maryland, USA.
Howard S FoxDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0003-2032-374X University of Nebraska Medical Center · USFrederick National Laboratory for Cancer Research · US
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MTulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MUNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2MUNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0MTherapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FOX, HOWARD S · 2000 to 2021
$37.7MUncovering HIV/opioid effects in the brain at the single cell level: transcription, chromatin accessibility, and reservoir analysis in the SIV/cART/morphine/rhesus monkey modelU01DA053624 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J, FOX, HOWARD S · 2021 to 2025
$8.2MMacrophages and Microglia, Gene Expression and Chromatin: Illuminating the Myeloid Viral Reservoir in the Brain through Single Cell AnalysesR21MH128057 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FOX, HOWARD S · 2021 to 2022
$421kNCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003INCI NIH HHS P30 CA036727NIDA NIH HHS U01 DA053624NIGMS NIH HHS P20 GM103427NIH HHS P51 OD011104NIMH NIH HHS P30 MH062261NIMH NIH HHS R21 MH128057
6 · The paper itselfAbstract
Human Immunodeficiency Virus (HIV) is widely acknowledged for its profound impact on the immune system. Although HIV primarily affects peripheral CD4 T cells, its influence on the central nervous system (CNS) cannot be overlooked. Within the brain, microglia and CNS-associated macrophages (CAMs) serve as the primary targets for HIV, as well as for the simian immunodeficiency virus (SIV) in nonhuman primates. This infection can lead to neurological effects and the establishment of a viral reservoir. Given the gaps in our understanding of how these cells respond
Indexed as
HIVmacrophagesmicroglianeuroHIVscRNA-seqSIV
Identifiers
PMID38617282
PMCPMC11014596
OpenAlexW4393985948
What OpenQuestion holds
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LicenceCC BY
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