Evidence map›Paper›PMID 38617275›Full record

ArticlebioRxiv : the preprint server for biology2024

The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain.

Ketan D Patel, Ryan A Oliver, Michael S Lichstrahl, Rongfeng Li, Craig A Townsend, Andrew M Gulick

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ketan D PatelDepartment of Structural Biology, University at Buffalo, SUNY, Buffalo, NY, 14203, USA.
Ryan A OliverDepartment of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218 USA.
Michael S LichstrahlDepartment of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218 USA.
Rongfeng LiDepartment of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218 USA.
Craig A TownsendDepartment of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218 USA.
Andrew M GulickDepartment of Structural Biology, University at Buffalo, SUNY, Buffalo, NY, 14203, USA.
Johns Hopkins University · USUniversity at Buffalo, State University of New York · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
National HTX Center: Enabling Access to State-of-the-Art Crystallization CapabilitiesR24GM141256 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Sarah Elizabeth Johnson Bowman · 2021 to 2026
$6.3M
Biosynthesis of Beta-Lactam AntibioticsR37AI014937 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG ARTHUR · 2004 to 2013
$5.2M
Biosynthesis of Beta Lactam AntibioticsR01AI121072 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG ARTHUR · 2016 to 2025
$4.9M
Structural Studies of Nonribosomal Peptide SynthesisR35GM136235 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GULICK, ANDREW M · 2020 to 2024
$2.0M
B LACTAM AND AMINO ACID DERIVED ANTIBIOTIC BIOSYNTHESISR01AI014937 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG A · 1985 to 2003
$1.5M
Biosynthesis of Beta-Lactam AntibioticsR56AI014937 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG ARTHUR · 2014 to 2014
$383k
NIAID NIH HHS R01 AI014937NIAID NIH HHS R01 AI121072NIAID NIH HHS R37 AI014937NIAID NIH HHS R56 AI014937NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R24 GM141256NIGMS NIH HHS R35 GM136235
6 · The paper itself

Abstract

Nonribosomal peptide synthetases (NRPSs) are responsible for the production of important biologically active peptides. The large, multidomain NRPSs operate through an assembly line strategy in which the growing peptide is tethered to carrier domains that deliver the intermediates to neighboring catalytic domains. While most NRPS domains catalyze standard chemistry of amino acid activation, peptide bond formation and product release, some canonical NRPS catalytic domains promote unexpected chemistry. The paradigm monobactam antibiotic sulfazecin is produced through the activity of a terminal thioesterase domain that catalyzes an unusual β-lactam forming reaction in which the nitrogen of the C-terminal

Indexed as

Nonribosomal Peptide SynthetaseNRPSthioesteraseβ-lactam antibiotic

Identifiers

PMID38617275
PMCPMC11014566
OpenAlexW4394063260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.