Evidence map›Paper›PMID 38617256›Full record

ArticlebioRxiv : the preprint server for biology2024

Pervasive loss of regulated necrotic cell death genes in elephants, hyraxes, and sea cows (

Meaghan Birkemeier, Arianna Swindle, Jacob Bowman, Vincent J Lynch

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Meaghan BirkemeierDepartment of Biological Sciences, University at Buffalo, SUNY, 551 Cooke Hall, Buffalo, NY, USA.
Arianna SwindleDepartment of Biological Sciences, University at Buffalo, SUNY, 551 Cooke Hall, Buffalo, NY, USA.
Jacob BowmanDepartment of Biological Sciences, University at Buffalo, SUNY, 551 Cooke Hall, Buffalo, NY, USA.
Vincent J LynchDepartment of Biological Sciences, University at Buffalo, SUNY, 551 Cooke Hall, Buffalo, NY, USA.ORCID 0000-0001-5311-3824
University at Buffalo, State University of New York · US

Funding

Determining the contribution of gene duplication to the resolution of healthy aging in long-lived speciesR56AG071860 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LYNCH, VINCENT J. · 2021 to 2021
$313k
NIA NIH HHS R56 AG071860
6 · The paper itself

Abstract

Gene loss can promote phenotypic differences between species, for example, if a gene constrains phenotypic variation in a trait, its loss allows for the evolution of a greater range of variation or even new phenotypes. Here, we explore the contribution of gene loss to the evolution of large bodies and augmented cancer resistance in elephants. We used genomes from 17 Afrotherian and Xenarthran species to identify lost genes, i.e., genes that have pseudogenized or been completely lost, and Dollo parsimony to reconstruct the evolutionary history of gene loss across species. We unexpectedly discovered a burst of gene losses in the Afrotherian stem lineage and found that the loss of genes with functions in regulated necrotic cell death modes was pervasive in elephants, hyraxes, and sea cows (

Identifiers

PMID38617256
PMCPMC11014510
OpenAlexW4394012299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.