Evidence map›Paper›PMID 38617237›Full record

ArticlebioRxiv : the preprint server for biology2024

Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase.

Rohit Singh, Rongrong Jiang, Jessica Williams, Prakashkumar Dobariya, Filip Hanak, Jiashu Xie, Patrick E Rothwell, Robert Vince, Swati S More

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rohit SinghCenter for Drug Design, College of Pharmacy, University of Minnesota, MN, USA.
Rongrong JiangCenter for Drug Design, College of Pharmacy, University of Minnesota, MN, USA.
Jessica WilliamsCenter for Drug Design, College of Pharmacy, University of Minnesota, MN, USA.
Prakashkumar DobariyaCenter for Drug Design, College of Pharmacy, University of Minnesota, MN, USA.
Filip HanakDepartment of Neuroscience, University of Minnesota Medical School, Minneapolis, MN, USA.
Jiashu XieCenter for Drug Design, College of Pharmacy, University of Minnesota, MN, USA.
Patrick E RothwellDepartment of Neuroscience, University of Minnesota Medical School, Minneapolis, MN, USA.
Robert VinceCenter for Drug Design, College of Pharmacy, University of Minnesota, MN, USA.
Swati S MoreCenter for Drug Design, College of Pharmacy, University of Minnesota, MN, USA.
University of Minnesota · USUniversity of Minnesota System · US

Funding

Domain-specific inhibition of angiotensin-converting enzyme as a therapeutic strategy for opioid use disordersR01DA056675 · NIDA · UNIVERSITY OF MINNESOTA · PI Swati S More, Patrick Rothwell · 2022 to 2026
$2.9M
Identification of small molecules that regulate endogenous opioid signaling by inhibiting angiotensin converting enzymeR01DA056331 · NIDA · UNIVERSITY OF MINNESOTA · PI Swati S More, Patrick Rothwell · 2022 to 2026
$2.9M
NIDA NIH HHS R01 DA056331NIDA NIH HHS R01 DA056675
6 · The paper itself

Abstract

The endogenous opioid system regulates pain through local release of neuropeptides and modulation of their action on opioid receptors. However, the effect of opioid peptides, the enkephalins, is short-lived due to their rapid hydrolysis by enkephalin-degrading enzymes. In turn, an innovative approach to the management of pain would be to increase the local concentration and prolong the stability of enkephalins by preventing their inactivation by neural enkephalinases such as puromycin sensitive aminopeptidase (PSA). Our previous structure-activity relationship studies offered the S-diphenylmethyl cysteinyl derivative of puromycin (

Indexed as

analgesiaenkephalinmetabolismmolecular modelingopioid receptorpuromycin aminonucleosidePuromycin sensitive aminopeptidase

Identifiers

PMID38617237
PMCPMC11014559
OpenAlexW4393903070

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.