Evidence map›Paper›PMID 38617230›Full record

ArticlebioRxiv : the preprint server for biology2024

Functional activation of dorsal striatum astrocytes improves movement deficits in hemi-parkinsonian mice.

Wesley R Evans, Sindhuja S Baskar, Ana Raquel Castro E Costa, Sanya Ravoori, Abimbola Arigbe, Rafiq Huda

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Wesley R EvansWM Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway NJ, 08854, USA.
Sindhuja S BaskarWM Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway NJ, 08854, USA.
Ana Raquel Castro E CostaWM Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway NJ, 08854, USA.
Sanya RavooriWM Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway NJ, 08854, USA.
Abimbola ArigbeWM Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway NJ, 08854, USA.
Rafiq HudaWM Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway NJ, 08854, USA.ORCID 0000-0002-6814-9966
Rutgers, The State University of New Jersey · USRutgers Sexual and Reproductive Health and Rights · NL

Funding

Molecular Neuroscience of Alcohol and Drug Abuse Research TrainingT32AA028254 · NIAAA · RUTGERS, THE STATE UNIV OF N.J. · PI ASTON-JONES, GARY S., SARKAR, DIPAK KUMAR · 2019 to 2023
$1.3M
Prefrontal circuits for attention and motor planningR00MH112855 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI HUDA, RAFIQ · 2020 to 2022
$742k
NIAAA NIH HHS T32 AA028254NIMH NIH HHS R00 MH112855
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal inputs, which causes striatal network dysfunction and leads to pronounced motor deficits. Recent evidence highlights astrocytes as a potential local source of striatal network modulation. However, it remains unknown how dopamine loss affects striatal astrocyte activity and whether astrocyte activity regulates behavioral deficits in PD. We addressed these questions by performing astrocyte-specific calcium recordings and manipulations using

Identifiers

PMID38617230
PMCPMC11014576
OpenAlexW4393868017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.