Evidence map›Paper›PMID 38617224›Full record

ArticlebioRxiv : the preprint server for biology2024

A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use.

Yihe Weng, Johann Kruschwitz, Laura M Rueda-Delgado, Kathy Ruddy, Rory Boyle, Luisa Franzen, Emin Serin, Tochukwu Nweze, Jamie Hanson, Alannah Smyth and 26 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 17 institutions in 9 countries.

Yihe WengSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.ORCID 0009-0005-2628-9492
Johann KruschwitzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Laura M Rueda-DelgadoSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.ORCID 0000-0002-8730-8977
Kathy RuddySchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.
Rory BoyleSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.ORCID 0000-0003-0787-6892
Luisa FranzenSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.
Emin SerinDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Tochukwu NwezeDepartment of Psychology, University of Utah, USA.
Jamie HansonDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Learning Research & Development Center, University of Pittsburgh, Pittsburgh, PA, USA.
Alannah SmythSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.
Tom FarnanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Sylvane DesrivièresCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, United Kingdom.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.ORCID 0000-0003-0111-5996
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli; Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli; Gif-sur-Yvette; and AP-HP. Sorbonne University, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli; Gif-sur-Yvette; and Psychiatry Department, EPS Barthélémy Durand, Etampes, France.
Jane McGrathDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.ORCID 0000-0002-1242-8990
Tomáš PausDepartments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hosptalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075, Göttingen, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Michael N SmolkaCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Germany.ORCID 0000-0001-5398-5569
Nilakshi VaidyaCentre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.ORCID 0000-0002-2790-7281
IMAGEN Consortium
Trinity College Dublin · IEHumboldt-Universität zu Berlin · DECentre National de la Recherche Scientifique · FRHeidelberg University · DECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRKing's College London · GBTechnische Universität Dresden · DEFudan University · CNPhysikalisch-Technische Bundesanstalt · DEQueen's University Belfast · GBUniversitätsmedizin Göttingen · DEUniversity of Mannheim · DEUniversity of Nottingham · GBUniversity of Pittsburgh · USUniversity of Toronto · CAUniversity of Utah · USUniversity of Vermont · US

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238NIMH NIH HHS R01 MH085772
6 · The paper itself

Abstract

Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substance-use or a marker of the inclination to engage in such behaviour. This study explored the relationship between sustained attention and substance use across a longitudinal span from ages 14 to 23 in over 1,000 participants. Behaviours and brain connectivity associated with diminished sustained attention at age 14 predicted subsequent increases in cannabis and cigarette smoking, establishing sustained attention as a robust biomarker for vulnerability to substance use. Individual differences in network strength relevant to sustained attention were preserved across developmental stages and sustained attention networks generalized to participants in an external dataset. In summary, brain networks of sustained attention are robust, consistent, and able to predict aspects of later substance use.

Identifiers

PMID38617224
PMCPMC11014614
OpenAlexW4394061304

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.