Evidence map›Paper›PMID 38617223›Full record

ArticlebioRxiv : the preprint server for biology2024

Dynamic Tracking of Native Precursors in Adult Mice.

Suying Liu, Sarah E Adams, Haotian Zheng, Juliana Ehnot, Seul K Jung, Greer Jeffrey, Theresa Menna, Louise E Purton, Hongzhe Lee, Peter Kurre

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Suying LiuComprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-3947-8151
Sarah E AdamsComprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Haotian ZhengDepartment of Biostatistics, Epidemiology and informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Juliana EhnotComprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Seul K JungComprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Greer JeffreyComprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Theresa MennaComprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Louise E PurtonStem Cell Regulation Unit, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.
Hongzhe LeeDepartment of Biostatistics, Epidemiology and informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Peter KurreComprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-2747-0099

Funding

Constrained Fetal Hematopoiesis and Clonal Restriction in Fanconi AnemiaR01HL150882 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI KURRE, PETER · 2020 to 2023
$2.4M
NHLBI NIH HHS R01 HL150882
6 · The paper itself

Abstract

Hematopoietic dysfunction has been associated with a reduction in the number of active precursors. However, precursor quantification at homeostasis and under diseased conditions is constrained by the scarcity of available methods. To address this issue, we optimized a method for quantifying a wide range of hematopoietic precursors. Assuming the random induction of a stable label in precursors following a binomial distribution, estimates depend on the inverse correlation between precursor numbers and the variance of precursor labeling among independent samples. Experimentally validated to cover the full dynamic range of hematopoietic precursors in mice (1 to 10

Identifiers

PMID38617223
PMCPMC11014561

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.