ArticlePain reports2024
Non-obese lipedema patients show a distinctly altered quantitative sensory testing profile with high diagnostic potential.
Article in Pain reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06770634 (Investigation of the Prevalence of Central Sensitization and Associated Factors in Patients With Lipedema), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Prevalence of Central Sensitization and Associated Factors in Patients With Lipedema
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Changes in plasma fatty acid composition in females with lipedema following low-carbohydrate vs low-fat diets and associations with pain reduction.Nutrition journal · 2026Trial
- Inter-Rater Reliability of the Progressive Pain Check Method for Standardized Pain Assessment in Lipedema.Life (Basel, Switzerland) · 2026Article
- Article
- Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.Current issues in molecular biology · 2026Review
- Central Sensitization, Pain, and Psychosocial Factors in Individuals with Lipedema: A Cross-Sectional Study.Aesthetic plastic surgery · 2026Article
- Current Evidence-Based Clinical Nutritional Approaches in Lipedema: A Scoping Review.Nutrition reviews · 2026Article
- Exploring quality of life and physical-physiological characteristics in obese patients with and without lipedema: insights from the LipObes study.BMC women's health · 2026Article
- Comorbidities in lipedema: toward a systemic perspective - a narrative review.Clinical and experimental medicine · 2026Review
- Epigenetic alterations of AKT1 orchestrate a metabolic reprogramming in advanced lipedema: translational insights from an integrated multi-omics study.Journal of translational medicine · 2026Article
- Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam.Nature communications · 2026Article
- The lipedema common case report form as a research tool: standardizing lipedema data collection.Frontiers in global women's health · 2026Article
- Lipedema as a hormone-sensitive stromal disorder: a four-pathway translational framework.Frontiers in cell and developmental biology · 2026Article
- The ıncidence of neuropathic pain and ıts ımpact on quality of life in patients with lipedema.Irish journal of medical science · 2025Article
- Examining the characteristic features of lipedema and the usefulness of BMI and WHtR in clinical evaluation.BMC women's health · 2025Article
- Evaluation of the Effectiveness of Compression Therapy Combined with Exercises Versus Exercises Only Among Lipedema Patients Using Various Outcome Measures.Life (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction and Objectives: Lipedema is a widespread severe chronic disease affecting mostly women. Characterized by painful bilateral fat accumulation in extremities sparing hands and feet, objective measurement-based diagnosis is currently missing. We tested for characteristic psychometric and/or sensory alterations including pain and for their potential for medical routine diagnosis. Methods: Pain psychometry was assessed using the German Pain Questionnaire. Sensory sensitivity toward painful and nonpainful stimuli was characterized in non-obese lipedema patients and matched controls using the validated quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain. Results: Lipedema patients showed no overt psychometric abnormalities. Pain was reported as somatic rather than psychosomatic aversive. All QST measurements were normal, but the z-score of pressure pain thresholds (PPT) was twofold reduced and the z-score of vibration detection thresholds (VDT) was two and a half times increased. Both thresholds were selectively altered at the affected thigh but not the unaffected hand. Receiver operating characteristic analysis of the combination of PPT and VDT of thigh vs hand into a PVTH score (PPT, VDT, thigh, hand-score) shows high sensitivity and specificity, categorizing correctly 95.8% of the participants as lipedema patients or healthy controls. Bayesian inference analysis corroborated the diagnostic potential of such a combined PVTH score. Conclusion: We propose to assess PPT and VDT at the painful thigh and the pain-free hand. Combination in a PVTH score may allow a convenient lipedema diagnosis early during disease development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.