Evidence map›Paper›PMID 38616743›Full record

ArticleAnti-cancer agents in medicinal chemistry2024

A Green Synthesis of Au-Ag Alloy Nanoparticles using Polydopamine Chemistry: Evaluation of their Anticancer Potency Towards Both MCF-7 Cells and their Cancer Stem Cells Subgroup.

Honglei Zhan, Shiyu Ding, Ruiyu Shen, Yulong Lv, Xinran Tian, Guie Liu, Chaoyue Li, Jihui Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Anti-cancer agents in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Honglei ZhanDepartment of Biopharmacy, School of Bioengineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, P.R. China.
Shiyu DingDepartment of Biopharmacy, School of Bioengineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, P.R. China.
Ruiyu ShenDepartment of Biopharmacy, School of Bioengineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, P.R. China.
Yulong LvDepartment of Biopharmacy, School of Bioengineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, P.R. China.
Xinran TianDepartment of Biopharmacy, School of Bioengineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, P.R. China.
Guie LiuDepartment of Biopharmacy, School of Bioengineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, P.R. China.
Chaoyue LiDepartment of Biopharmacy, School of Bioengineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, P.R. China.
Jihui WangDepartment of Biopharmacy, School of Bioengineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, P.R. China.
Dalian Polytechnic University · CNDongguan University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited chemotherapy efficacy and cancer stem cells (CSCs)-induced therapeutic resistance are major difficulties for tumour treatment. Adopting more efficient therapies to eliminate bulk-sensitive cancer cells and resistant CSCs is urgently needed.

methodsBased on the potential and functional complementarity of gold and silver nanoparticles (AuNPs or AgNPs) on tumour treatment, bimetallic NPs (alloy) have been synthesized to obtain improved or even newly emerging bioactivity from a combination effect. This study reported a facile, green and economical preparation of Au-Ag alloy NPs using biocompatible polydopamine (PDA) as a reductant, capping, stabilizing and hydrophilic agent.

resultsThese alloy NPs were quasi-spherical with rough surfaces and recorded in diameters of 80 nm. In addition, these alloy NPs showed good water dispersity, stability and photothermal effect. Compared with monometallic counterparts, these alloy NPs demonstrated a dramatically enhanced cytotoxic/pro-apoptotic/necrotic effect towards bulk-sensitive MCF-7 and MDA-MB-231 cells. The underlying mechanism regarding the apoptotic action was associated with a mitochondria-mediated pathway, as evidenced by Au3+/Ag+ mediated Mitochondria damage, ROS generation, DNA fragmentation and upregulation of certain apoptotic-related genes (Bax, P53 and Caspase 3). Attractively, these Au-Ag alloy NPs showed a remarkably improved inhibitory effect on the mammosphere formation capacity of MCF-7 CSCs.

conclusionAll the positive results were attributed to incorporated properties from Au, Ag and PDA, the combination effect of chemotherapy and photothermal therapy and the nano-scaled structure of Au-Ag alloy NPs. In addition, the high biocompatibility of Au-Ag alloy NPs supported them as a good candidate in cancer therapy.

Indexed as

Antineoplastic AgentsCell ProliferationDrug Screening Assays, AntitumorGoldGreen Chemistry TechnologyIndolesMetal NanoparticlesNeoplastic Stem CellsPolymersSilverAlloysApoptosisCell SurvivalDose-Response Relationship, DrugHumansMCF-7 CellsAlloysAntineoplastic AgentsGoldIndolespolydopaminePolymersSilveralloy nanoparticlesCancer stem cellschemo-thermotherapyMCF-7 cells.mitochondria-mediated apoptosispolydopamine

Identifiers

PMID38616743
OpenAlexW4394817951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.